The isolated fungi Myrothecium spp MRP001 represent an important source of biologically active compounds. The maximum biomass production was optimized (pH 6.5, 96 h at 30 °C) using OFAT (one factor at time) in six different medias, After 96 h of growth, Tryptone Soya Broth (TSB) and Potato Dextrose Broth (PDB) shows maximum spore account (2×10 8 CFU/ml) of Myrothecium spp MRP001. Screening of b...

An extract of Myrothecium verrucaria, a fungus which produces a range of 12,13-epoxytrichothecene toxins, was found to be resistant to T-2 toxin, one of its products. The epoxytrichothecenes are inhibitors of eukaryotic protein synthesis and normally bind to the 60S ribosomal subunit so as to inhibit peptidyltransferase activity. Ribosomes from M. verrucaria contain 60S subunits which are not s...

In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verruca...

Cellulolytic enzyme preparations active against various forms of cellulose have been reported by a number of investigators who have used a variety of different sources (8). Fungi which have been employed for the preparation of such extracts are Sporotrichum cards (15), Aspergillus oryxae (3,2), Merulius lachrymans (9), and Coniophora cerebella (7), while bacteria have included Bacterium protoxo...

Myrothecium roridum and M. verrucaria are two plant pathogenic species causing foliar spots in a large number of cultivated plants. This paper aims to study the causal agents of foliar spots in vegetable crops (sweet pepper, tomato, cucumber), ornamental plants (Spathiphyllum, Solidago canadensis, Anthurium, Dieffenbachia) and a solanaceous weed plant (Nicandra physalodes). Most of the isolates...