Diffuse alveolar damage (DAD) triggers neutrophilic inflammation in damaged tissues of the lung, but little is known about distinct roles tissue structural cells modulating recruitment neutrophils to areas. Here, by combining single-cell and spatial transcriptomics, using quantitative assays, we systematically analyze inflammatory cell states a mouse model DAD-induced after aerosolized intratra...

This  paper extends the notion of fuzzy $BCK$-subalgebras to fuzzy hyper $BCK$-subalgebras and defines an extended fuzzy $BCK$-subalgebras. This study  considers  a type of fuzzy hyper  $BCK$-ideals  in this  hyperstructure  and  describes   the  relationship  between hyper  $BCK$-ideals and  fuzzy hyper  $BCK$-ideals.  In fact, it tries to introduce   a  strongly  regular  relation  on hyper $...

A simple method is described, to prove some theorems for simple hyper K-algebras and to study positive implicative hyper K-ideals, weak (implicative ) hyper K-ideals in simple hyper K-algebras . Beside, some results on positive implicative and (weak) implicative simple hyper K-algebras are presented. Finally classification of simple hyper Kalgebras of order 4, which are satisfied in conditions ...

We present some connections between the max-min general fuzzy automaton theory and the hyper structure theory. First, we introduce a hyper BCK-algebra induced by a max-min general fuzzy automaton. Then, we study the properties of this hyper BCK-algebra. Particularly, some theorems and results for hyper BCK-algebra are proved. For example, it is shown that this structure consists of different ty...

anti-neutrophil cytoplasmic autoantibodies have been detected in patients with some autoimmune and vascular diseases such as wegner's granulomatosis, polyarthritis nodosa and systemic lupus erythematosus. indirect immunofluorescence technique has been employed to detect these autoantibodies. by this method, two general patterns of antineutrophil cytoplasmic antibodies were seen: a cytoplasmic (...

COPD is the major cause of morbidity and mortality across world. In addition to this, factor that contributing in this disease smoking. This kind problem occurs due airflow obstruction influences progressive accompanied hyper-responsiveness. The patients with Asthma overlap (ACO) have a poor quality life more rapid decline lung functions high mortality. Also, they consume disproportionate amoun...

in this study the programmed cell death (apoptosis) of human neutrophilic granulocytes was investigated in the presence and absence of fetal calf serum (fcs), cycloheximide and actinomycin-d. the results show that when fcs is omitted from cultures, apart from a decrease in viability, the percentage of apoptotic cells and dna fragmentation increases. apoptosis is accelerated in serum withdrawal ...

respiratory virus infection is a major cause of asthma exacerbation. however, the underlying mechanisms of  this exacerbation  are unknown. therefore,  to  determine  the mechanisms, we examined the effect of influenza infection in a murine model of asthma.mice were divided into four groups: the phosphate-buffered saline (pbs), house dust mite (hdm), influenza, and hdm/influenza groups. the inf...

A n association between hypertension and immune system activation has long been recognized as a potential mechanism of hypertensive end-organ damage. Indeed, recent accumulating evidence using mouse models of hypertension induced by angiotensin II (Ang II) supports the roles of T lymphocytes and macrophages in the pathogenesis of hyper-tension and its complications. 1 Curiously, although neutro...