nifedipine (nif) a 1, 4-dihydropyridine calcium channel antagonist, undergoes photodegradation to nitroso analogues of dehydronifedipine (ndnif) when exposed to sunlight. photodegradation products of nif have no clinical activity, so different formulations of nif must remain unchanged. if nif preparations become unstable in exposure to light, they could cause therapeutic failure. the present st...

mice were rendered tolerant and dependent to morphine by subcutaneous injection of morphine over a period of 5 days. the effects of acute and chronic administration of dihydropyridine calcium channel antagonist nifedipine on the development of tolerance and naloxone-precipitated morphine withdrawal signs were investigated. a single injection of nifedipine proved to be effective in inhibiting so...

OBJECTIVE A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival fibroblasts in vitro. We performed an in vivo experiment to determine whether Saireito has a therapeutic use in the treatment of nifedipine-induced gingival overgrowth. METHODS...

Normal tension glaucoma (NTG) is labelled when typical glaucomatous disc changes, visual field defects and open anterior chamber angles are associated with intraocular pressure (IOP) constantly below 21 mmHg. Chronic low vascular perfusion, Raynaud's phenomenon, migraine, nocturnal systemic hypotension and over-treated systemic hypertension are the main causes of normal tension glaucoma. Goldma...

Depression, a bewildering and burdensome illness, is one of the commonest psychiatric diseases. It is expected to be the second leading contributor to Global Disease Burden by 2020. The objective of the study was to determine the effect of nifedipine on the responses of imipramine, sertraline and furosemide in the forced swim test (FST) and tail suspension test (TST) in mice. Groups of mice wer...

the electrochemical behavior of nifedipine (i), nitrendipine(ii) and their photodegradation products has been studied by employing electrochemical techniques in chloroform and in 1:4 mixture of chloroform-isopropanol using piperidinium perchlorate (ppc) as supporting electrolyte. it has been shown that i and ii undergo in a 4e, 4h+ irreversible reduction reaction, while the reduction product, p...

patients with diabetes mellitus (dm), experience significant morbidity and mortality from microvascular retinopathy, nephropathy and neuropathy. hyperglycemia can induce diabetic complications through multiple pathways. activation of protein kinase c (pkc) by hyperglycemia is one of the pathways which causes diabetic complications. effect of nifedipine (a calcium channel blocker), and polymyxin...

Nifedipine has been shown to improve endothelial function. Recent studies have indicated that endothelial function is correlated with the number of circulating endothelial progenitor cells (EPCs), but it is unclear whether nifedipine affects the number and function of EPCs. The aims of this study were to determine the effects of nifedipine on the number and function of EPCs and to investigate t...