Toxicosis produced by nitrates and related compounds is a problem in man and in domestic animals. The most prominent effect of nitrate and nitrite is the conversion of hemoglobin to methemoglobin. Nitrate must be reduced to nitrite before excessive -methemoglobinemia occurs. Nitrites are therefore several times more toxic than nitrates. -· Pharmacologically, KN03 had been used as a diuretic, an...

Ingestion of nitrates in drinking water has long been thought to be a primary cause of acquired infantile methemoglobinemia, often called blue baby syndrome. However, recent research and a review of historical cases offer a more complex picture of the causes of infantile methemoglobinemia. Gastrointestinal infection and inflammation and the ensuing overproduction of nitric oxide may be the caus...

Combination therapy with hydralazine and nitrates can improve outcomes in patients with heart failure and low ejection fraction. However, this combination is underused in clinical practice for several reasons, including side effects related to hydralazine and polypharmacy. Some of the benefits seen with hydralazine, including afterload reduction and attenuation of nitrate tolerance, have also b...

nitrate has been the most common chemical contaminant in water resource. this ion is introduced into the water via different ways, but more items of nitrate pollution was connected with farming-based drainage and sewage effluent. in this descriptive-analytical study, groundwater nitrate and nitrite concentrations of 8 wells on dehloran, ilam, iran, were analyzed in 2015 to determine the causes ...

background contamination of water resources with nitrate is a serious environmental problem in many regions of the world. in addition, this problem has been observed in some regions of iran. as nitrate is threatening for human health and environment, it must be decreased to standard levels in drinking water. objectives the purpose of this research was to model the nitrate removal from water by ...

Previously, it was shown that the D enantiomer of isoidide dinitrate was 10-fold more potent than the L enantiomer and 10-fold less potent than glyceryl trinitrate for stimulating cyclic GMP accumulation and relaxation of isolated rat aorta. In the present study, these organic nitrates were tested for their ability to induce tolerance to organic nitrate-induced relaxation, cyclic GMP accumulati...

Wuandcolleaguesprovide a fascinating insight into the potential role of nitrates in aggressive prostate cancer (1) with the suggestion that higher nitrates might be beneficial. Wu and colleagues also draw attention to the emerging relation of higher nitrates with lower cardiovascular disease risk (1). Despite a meticulously conducted study, the authors are rightly cautious in interpreting their...

We describe a nearly explicit chemical mechanism for isoprene photooxidation guided by chamber studies that include time-resolved observation of an extensive suite of volatile compounds. We provide new constraints on the chemistry of the poorly-understood isoprene δ-hydroxy channels, which account for more than one third of the total isoprene carbon flux and a larger fraction of the nitrate yie...

Organic nitrates are commonly used in angina pectoris and ischemic cardiomyopathy. In order to optimize their effectiveness and patient convenience, several aspects must be observed. Adequate doses, suitable dosage forms and asymmetric pattern of usage to prevent the nitrate tolerance are some factors that a physician must be familiar with. The objective of the present study was to define the p...