The nucleocytoplasmic shuttling of SOX transcription factors play a crucial role in the regulation of SOX protein functions during development. In this study, we have demonstrated two nuclear localization signals in the HMG box of Eriocheir sinensis SOX14A and SOX14B. These two conserved nuclear localization signals mediate nuclear transport. The N-termini nuclear localization signal mediates t...

The goal of this article is to provide a comprehensive catalog of those proteins documented to exhibit dual localization, being found in both the extracellular compartment (cell surface and extracellular medium) as well as the intracellular compartment (cytosol and nucleus). A large subset of these proteins that show dual localization is found both in the nucleus and outside of cells. Proteins ...

manipulating spindle by laser, we showed that the spindle asymmetry is essential for asymmetric nuclear localization of b-catenin. Because a kinesin inhibitor disrupted asymmetry of b-catenin localization, we propose that kinesin dependent transport of b-catenin along astral microtubules causes the enhancement of nuclear b-catenin export. This process occurs more efficiently in the anterior sid...

manipulating spindle by laser, we showed that the spindle asymmetry is essential for asymmetric nuclear localization of b-catenin. Because a kinesin inhibitor disrupted asymmetry of b-catenin localization, we propose that kinesin dependent transport of b-catenin along astral microtubules causes the enhancement of nuclear b-catenin export. This process occurs more efficiently in the anterior sid...

Spinocerebellar ataxia type 3 (SCA3)/Machado Joseph disease results from expansion of the polyglutamine domain in ataxin-3 (Atx3). Atx3 is a transcriptional co-repressor, as well as a deubiquitinating enzyme that appears to function in cellular pathways involved in protein homeostasis. In this study, we show that interactions of Atx3 with valosin-containing protein and hHR23B are dynamic and mo...

Expression of the hepatitis B virus core antigen (HBcAg) in mouse NIH 3T3 fibroblasts has been shown previously (A. McLachlan et al., J. Virol. 61:683-692, 1987) to result in the nuclear localization of this polypeptide. Since the carboxyl terminus of HBcAg contains four clusters of arginine residues which resemble nuclear localization sequences identified in other nuclear proteins, a series of...

The major DNA-binding protein, or infected-cell protein 8 (ICP8), encoded by herpes simplex virus can localize to the cell nucleus independently of other viral proteins. To define the nuclear localization signals within ICP8, we performed several forms of mutagenesis on the cloned ICP8 gene. Deletion analysis of the ICP8 gene showed that several portions of ICP8 are involved in its nuclear loca...

The nucleocapsid (N) protein of several members within the order Nidovirales localizes to the nucleolus during infection and after transfection of cells with N genes. However, confocal microscopy of N protein localization in Vero cells infected with the severe acute respiratory syndrome coronavirus (SARS-CoV) or transfected with the SARS-CoV N gene failed to show the presence of N in the nucleo...

Following the original approach introduced by T. Cazenave and P.L. Lions in [4] we prove the existence and the orbital stability of standing waves for the following class of NLS: (0.1) i∂tu + ∆u − V (x)u + Q(x)u|u| p−2 = 0, (t, x) ∈ R × R n , 2 < p < 2 + 4 n and (0.2) i∂tu − ∆ 2 u − V (x)u + Q(x)u|u| p−2 = 0, (t, x) ∈ R × R n , 2 < p < 2 + 8 n under suitable assumptions on the potentials V (x) ...