We follow a research thread studying the predecessor problem on “smooth” distribution families. We propose a conceptually simpler solution utilizing wellknown results from much better studied variant of the problem that assumes nothing about the input. As a side effect, we are able to extend the range of handled input distributions for the most studied case needing expected O (log log n) time, ...

In this paper the known upper bound 10 for the number of Diophantine quintuples is reduced to 6.8·10. The key ingredient for the improvement is that certain individual bounds on parameters are now combined with a more efficient counting of tuples, and estimated by sums over divisor functions. As a side effect, we also improve the known upper bound 4 ·10 for the number of D(−1)-quadruples to 5 ·...

Glucocorticoid (GC)-induced ocular hypertension and iatrogenic glaucoma still are a major side effect associated with GC therapy, especially with the increased use of intravitreally administered GCs for a variety of retinal conditions. In this issue, Overby and colleagues investigated GC-induced ocular hypertension in mice. They built on the success of Whitlock and coworkers, who previously rep...

Purpose The objective of this study was to investigate the pharmacologic characteristics of omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure (IOP)-lowering agent, with better IOP control and fewer side effects than other prostanoid receptor agonists such as prostaglandin F receptor (FP) agonists. Methods Binding activities of OMDI and its hydrolyzed form, omid...

Purpose: The present study aimed to review the effect of dehydration during Ramadan fasting on the health and ocular parameters leading to changes in eye function. Methods: Articles included in the study were taken from Pub Med, Ovid, Web of Science and Google Scholar up to 2014.Related articles were also obtained from scientific journals in fasting and eye. Results: Dehydration and nutrition c...

CASE REPORTS We describe 2 patients who developed ocular side effects during treatment with topiramate. One was a 16-year-old woman with generalized seizures who developed a homonymous hemianopia after using topiramate 125 mg per day for 12 weeks, and the other was a 24-year-old epileptic female who developed a bilateral maculopathy after using topiramate 150 mg per day for 8 weeks. DISCUSSIO...

While the mammalian eye is seldom considered an organ of drug metabolism, the capacity for biotransformation is present. Compared to the liver, the metabolic capabilities of the eye are minuscule; however, phase I and phase II metabolic activities have been detected in various ocular structures. The careful consideration of ocular tissue metabolic processes within the eye has important implicat...