OBJECTIVES In this research, zeolite X and zeolite Y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. MATERIALS AND METHODS A soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. Gravimetric methods and IR spectra of prepared formulations were used to assess drug loading efficiencies into z...

Article type: Original article Objective(s): In this research, zeolite X and zeolite Y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. Materials and Methods: A soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. Gravimetric methods and IR spectra of prepared formulations were used to assess...

Triazine-based antiprotozoal agents are known for their lipophylic characteristics and may therefore be expected to be well absorbed following oral administration. However, although an increase in lipid solubility generally increases the absorption of chemicals, extremely lipid-soluble chemicals may dissolve poorly in gastrointestinal (GI) fluids, and their corresponding absorption and bioavail...

Abstract Solid lipid nanoparticles (SLNs), the spheroidal-shaped, colloids state lipophilic-natured, innovative nanoscale particulate materials, are being concurrently prepared by quality-by-design approach for cellular and sub-cellular delivery of drugs other payloads with facilitated physicochemical characteristics targeted delivery. The drugs, pharmaceuticals biopharmaceutical genes to disea...

conclusions this study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of s/c, water and oil percentage in formulations. background self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polym...

Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains. A Morris water maze was used to evaluate the status of th...

D-allulose is a C-3 epimer of D-fructose and has recently been investigated for its hypoglycemic effects. In the present study, the effects of D-allulose on glucose metabolism were evaluated in healthy dogs administrated sugar or food. The oral administrations of D-allulose decreased plasma glucose concentrations after oral glucose or maltose administration, with a diminished plasma insulin ris...

Bioinequivalence of glassy and crystalline indomethacin was investigated in rabbits. In vivo absorption studies were carried out by determining the plasma levels of indomethacin following oral and rectal administrations in rabbits. The A UC (area under the concentration–time curve) and the maximum plasma level following the administration of the glassy preparation were larger than those in the ...

in the present study, the effects of the acute and chronic oral administrations (po) of curcumin in the absence and presence of morphine and naloxone was investigated on the sensation of acute corneal pain in rats. acute corneal pain was induced by the local application of hypertonic saline (5 m nacl) on the corneal surface, and the number of eye wipes was then counted for 30 s. subcutaneous (s...