BACKGROUND Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems to have positive skeletal effects. To further explore these effects we have examined the effect of the PPARalpha agonists fenofibrate and Wyeth 14643, and the PPARgamma agonist pioglitazone, on bone mineral density (BMD), bone...

Grewal, Michelle, Janis Cuevas, Gautam Chaudhuri, and Lauren Nathan. Effects of calcitonin gene-related peptide on vascular resistance in rats: role of sex steroids. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H2063–H2068, 1999.—It has been demonstrated in reflex-intact animals that the sensitivity to calcitonin gene-related peptide (CGRP) is increased during pregnancy and that this action i...

It has been demonstrated in reflex-intact animals that the sensitivity to calcitonin gene-related peptide (CGRP) is increased during pregnancy and that this action is mediated by sex steroids but not by nitric oxide (NO). We assessed the effects of CGRP in the following groups of anesthetized ganglion-blocked rats: 1) pregnant, 2) ovariectomized, and 3) ovariectomized and treated with estradiol...

This study aimed at evaluating the bone repair process in ovariectomized rats submitted to an irradiation procedure. For this purpose, one hundred rats were randomly divided in four experimental groups: control, ovariectomized, irradiated and irradiated/ovariectomized. A bone defect was made on all animals' tibias. Three days after surgery, only irradiated and irradiated/ovariectomized rats rec...

objective(s): studies have reported that whole body vibration (wbv) played a vital role in bone remodeling. circulating serotonin is also involved in negative regulating bone mass in rodents and humans. however, both wbv and inhibition of serotonin biosynthesis may suppress receptor activator of nuclear factor-kappab ligand (rankl)-induced osteoclastogenesis in vitro . the purpose of the curren...

INTRODUCTION Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS A total of 24 female Sprague-Dawley rats (200-250 g) were ...

introduction: several studies indicate that estrogen use increase performance on some tests of cognition especially in postmenopausal women. these steroids have many side effects, thus, other estrogenic agents with fewer side effects are needed to develop alternative treatment strategies. the main objection of this study was to evaluate the effects of different doses of dietary soy meals (with ...