The pin-bone interface is the least stable component of the external skeletal fixator. Concerns exist regarding the ability to obtain adequate implant purchase in poor quality bone. Consequently, reduced bone quality has been viewed as a contra-indication for the use of external skeletal fixators. The aim of this study was to investigate the holding power of two different fixator pin designs in...

Aim: Melatonin promoted osteoblast differentiation and causes an increase in levels of markers bone proliferation. Ramelteon (RAMEL) activates melatonin receptors binds to these as non-selective. In this study, we investigated the preventive effects agonist RAMEL on osteoporosis by radiological, histological, molecularly.Methods: Groups 1: Control, Group 2: Osteoporosis: Overectomized group (OP...

The aim of this study was to examine the changes in serum cytokine levels (Il-1α, Il-6, TNF-α) in ovariectomized rats with and without replacement estrogen therapy. Female Wistar rats were used. Rats were qualified for the following groups: Cl control, SH sham-operated, OV after ovariectomy, OVH after ovariectomy receiving 17 β-estradiol in three different doses (1.25, 12.5, 125 μg) during seve...

This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes. Myocytes were isolated from anesthetized C57BL/6 female mice. Animals received an ovariectomy or sham-operation at one month and were aged to ~24 months. Excitation-contraction coupling parameters were...

The quantity and quality of maxillary and mandibular bone have long been a focus of attention for dental clinicians. The mandibular condyle is a major growth site and plays an important role during mandibular growth. The aim of the present study was to evaluate the effects of long-term extremely low frequency magnetic field (ELF-MF) and hormonal changes produced by bilateral ovariectomy on the ...

Acute exogenous estrogen administration enhances endothelial function in postmenopausal women. To evaluate the effect of endogenous estrogen on endothelium-dependent vasodilation, in 10 fertile normotensive women (age range 45 to 51 years) we studied the changes in forearm blood flow (strain-gauge plethysmography) induced by intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, 1.5 micrograms.100 ...

ÐEstrogens can in ̄uence the survival, plasticity and function of many adult neurons. Many of these effects, such as neurite outgrowth and increased dendritic spine density, are mediated by changes in neuronal cytoskeletal architecture. Since neuro®lament proteins play a key role in the maintenance and remodeling of the neuronal cytoskeleton, we postulated that changes in neuro®lament light chai...

BACKGROUND Estradiol is known to inhibit food intake (FI), water intake (WI) and body weight (BW) across the species including women and it is most evident in rats. Ovariectomy in rats and menopause in women produce hyperphagia and obesity. Estradiol substitution in ovariectomized (OVX) rats and hormone replacement in women reverses these changes suggesting that lack of estradiol causes eating ...