Antibiotic and metal resistance can occur together in the environment be linked by same detoxication mechanism (cross-resistance). The understanding of this linkage may a key to further study spread antibiotic non-hospital worldwide. In our study, we examined overproduction efflux pumps as possible cross-resistance isolates originating from industrial mine tailings. Resistance metals (Cu, Ni, Z...

The [URE3] and [PSI(+)] prions are infectious amyloid forms of Ure2p and Sup35p. Several chaperones influence prion propagation: Hsp104p overproduction destabilizes [PSI(+)], whereas [URE3] is sensitive to excess of Ssa1p or Ydj1p. Here, we show that overproduction of the chaperone, Sse1p, can efficiently cure [URE3]. Sse1p and Fes1p are nucleotide exchange factors for Ssa1p. Interestingly, del...