Epithelia from many tissues express protease-activated receptors (PARs) that play a major role in several different physiological processes. In this study, we examined their capacity to modulate IL-6, IL-8, and PGE(2) production in both the A459 and BEAS-2B cell lines and primary human bronchial epithelial cells (HBECs). All three cell types expressed PAR-1, PAR-2, PAR-3, and PAR-4, as judged b...

Le traitement des hemorroides peut-etre dif­feren: selon l'intens,ite et la frequence de leur manifestations.  1. Crise hemorroidaire avec douleur, hemor­ragie et parfois peUt procidence, a la suite d'un repas, fatigue, etc ... sans precedent, est traiter par des moyennes medicaux apropries. 2. Les vrais hemorroides doivent etre traite soit par des methodes Sclerosantes, soit par des meth...

Protease-activated receptor-2 (PAR-2) plays an extensive role in the regulation of digestive exocrine secretion. The present study examined whether PAR-2-related peptides could modulate tear secretion in rats and analyzed the underlying mechanisms. SLIGRL-NH(2), a PAR-2-activating peptide (PAR-2-AP) derived from mouse/rat PAR-2, when administered i.v. in combination with amastatin, an aminopept...

Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced lung fibrosis is diminished in both PAR-1 and PAR-2 deficient mice. We thus have been suggested that...

BACKGROUND Correctional Officers (COs) have among the highest injury rates and poorest health of all the public safety occupations. The HITEC-2 (Health Improvement Through Employee Control-2) study uses Participatory Action Research (PAR) to design and implement interventions to improve health and safety of COs. METHOD HITEC-2 compared two different types of participatory program, a CO-only "...

XPS and NRA depth profiling of nitrogen and carbon simultaneously 1 implanted into copper to synthesize C3N4 like compounds 2 J. L. Colaux, P. Louette , G. Terwagne 3 Research center in Physics of Matter and Radiation (PMR), 4 1 Laboratoire d’Analyses par Réactions Nucléaires (LARN), 5 2 Laboratoire Interdisciplinaire de Spectroscopie Electronique (LISE), 6 University of Namur (FUNDP), 7 61 Rue...