intravenous glucocorucoid pulse therapy is a common treatment for immunologically origin diseases but it can not be considered a completely bening treatment.the effects of long term administration of glucocorticoids on calcium and phosphorus metabolism are week known ,but is less in known about the effect of pluse therapy.the purpose of this study was to investigate the effect of methylpredn...

We previously suggested that after synthesis, proparathormone is transferred from rough endoplasmic reticulum to the Golgi region where its conversion to parathormone occurs. We have attempted to define more closely this transfer process. In the first type of study, bovine parathyroid slices were incubated with [3H]leucine for 10 min and then radioisotope labeling was restricted by addition of ...

It is still not completely clear whether carbamazepine causes alterations in vitamin D status and in bone metabolism. Th e objective of this study was to investigate the eff ects of carbamazepine on serum levels of -hydroxyvitamin D and on biomarkers of bone formation and resorption in healthy rats. Levels of calcium, hydroxyvitamin D, parathormone, C-telopeptide, bone specifi c alkaline ph...

Background: In this study, we determined the serum levels of IL-17A and IL-10 in context with 1, 2 dihydroxy vitamin D3, parathormone and Ca2+/Pi ions to investigate their pathological or protective roles respectively in bone metabolism. Methods: The bone mineral density (BMD) was determined for 1203 participants using energy X-ray absorptiometry. Subjects with a history of diseases and usin...

The aim of this study was to determine circannual changes in the serum concentrations of thyroxine, calcitonin and parathormone in mature and immature red deer females. Blood samples from 8 hinds were collected monthly for 26 months. Secretions of thyroxine and calcitonin showed circannual rhythms with significantly higher levels in the immature hinds compared to the mature animals (p<0.05). Fo...

1. The effect of vasopressin on the tubular reabsorption of phosphate was studied in both water-restricted and water-loaded man at different baseline rates of phosphate excretion. The latter was varied by altering phosphate intake or by administering aluminium hydroxide to reduce phosphate absorption from the gut. 2. It was found that when phosphate excretion was high, vasopressin had no consis...

Parathormone (PTH) is composed of four glands embedded in the thyroid gland, but its function is mainly to keep calcium in the blood within normal range. It has got sensitive receptors that trigger the PTH to act in correcting serum calcium. As calcium is important for the normal functioning of many organs including vital organs like heart and brain, the PTH has to be prompt in maintaining calc...

We prospectively evaluated the bone changes associated with proteasome inhibition using single agent bortezomib in relapsed or refractory myeloma patients. Ten patients received bortezomib 1.3 mg/m(2) per days 1, 4, 8 and 11 for three 21-day cycles, and 6 patients received 1 mg/m(2) per day with the same schedule. Bone architecture and metabolism changes were assessed by bone markers, micro-CT,...

Neonatal primary hyperparathyroidism (NPHT) is associated with an inactivating homozygous mutation of the calcium sensing receptor (CaSR). The CaSR is expressed most abundantly in the parathyroid glands and the kidney and regulates calcium homeostasis through its ability to modulate parathormone secretion and renal calcium reabsorption. NPHT leads to life threatening hypercalcemia, nephrocalcin...