The finding that human factor Vlll (NIII) inhibitor antibodies with C2 domain epitopes interfere with the binding of Nlll to phosphatidylserine (PS) suggested that this is the mechanism by which they inactivate NIII. We constructed a recombinant C2 domain polypeptide and demonstrated that it bound to all six human inhibitors with Nlll light chain specificity. Thus, some antibodies within the po...

The present investigation describes the synthesis and structural study of a metal-zinc ligand [NiL].H2O, which was used to generate trinuclear complex formulated as {Ni(m-L)Na(m-L)Ni}.(SCN)0.6.(Cl)0.4. title compound crystallizes in tetragonal space group I41/acd with following unit cell parameters: = 185403(5) Å, c 51.925(2) V 17849.0(3) Å3, Z 16, R1 0.074 wR2 0.209. Each organic molecule acts...

The entire life cycle of Rhodnius domesticus, fed weekly on mice, was studied under controlled conditions. Aspects related to hatching, life time, mortality, feeding behaviour and fecundity for each stage of the insect life-cycle were evaluated. The hatching rate observed in 100 eggs was 57% and the mean time of hatching was 15.6 days. Forty-six nymphs (80.7%) completed the cycle and the mean t...

Aspects related to hatching, life time, mortality, feeding behaviour and fecundity for each stage of Triatoma pallidipennis life-cycle were evaluated. The hatching rate observed for 200 eggs was 60% and the average time of hatching was 18 days. Eighty nymphs (N) (40%) completed the cycle and the average time from NI to adult was 168. 7+/-11.7days. The average span in days for each stage was 18....

The solvated title compound, bis-[2,6-bis-(1-{[4-(di-methyl-amino)-phen-yl]imino-κN}eth-yl)pyridine-κN]nickel(II) dichloride-di-chloro-methane-water (1/2/2), [Ni(C25H29N5)2]Cl2·2CH2Cl2·2H2O, represents a nickel(II) bis-(pyridine di-imine) complex with electron-donating di-methyl-amino-phenyl substituents. The complex crystallizes as a water/di-chloro-methane solvate with Z' = 2, thus the asymme...

The complete mol-ecule of the title hydrazine carbodi-thio-ate complex, [Ni(C19H21N2S2)2], is generated by the application of a centre of inversion. The NiII atom is N,S-chelated by two hydrazinecarbodi-thio-ate ligands, which provide a trans-N2S2 donor set that defines a distorted square-planar geometry. The conformation of the five-membered chelate ring is an envelope with the NiII atom being...

Meiosis in mammalian oocytes includes two asymmetric meiotic divisions that result in extrusion of the first and second polar bodies (PBI and PBII, respectively). Fyn, an Src family kinase (SFK), colocalizes with filamentous actin (F-actin) at the meiotic cleavage furrow area of mouse oocytes. In this paper, these studies are extended to rat oocytes. Furthermore, inhibition of Fyn decreased the...