BACKGROUND Rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods are used increasingly for tacrolimus (TRL) monitoring but show a negative difference with respect to a microparticle immunoassay (MEIA). This report examines possible reasons for this difference between methods. METHODS We collected 1156 blood samples from 277 adult and 121 pediatric recipients of liver, renal,...

Cognitive and neuropsychological impairments are well documented in adult multiple sclerosis (MS). Research has only recently focused on cognitive disabilities in pediatric cases, highlighting some differences between pediatric and adult cases. Impairments in several functions have been reported in children, particularly in relation to attention, processing speed, visual-motor skills, and langu...

BACKGROUND Daclizumab, a humanized monoclonal antibody specific for the interleukin 2 receptor α chain, reduces clinical and magnetic resonance imaging disease activity in patients with adult-onset multiple sclerosis (MS) as monotherapy or add-on therapy with interferon. OBJECTIVE To report the use of daclizumab in pediatric-onset MS. DESIGN Case series. SETTING Two comprehensive pediatri...

Comparison between cephalometrics measure using anatomic and metallic porion point Fábio Lourenço Romano1 Edvaldo Luiz Ramalli2 Stenyo Wanderley Tavares2 João Sarmento Pereira Neto3 Maria Beatriz Borges de Araújo Magnani3 Darcy Flávio Nouer3 1MS Orthodontics, Pediatric Dentistry Department, University of Campinas, Piracicaba Dental School – Brazil; Professor, Department Restorative Prosthestic,...

Multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the central nervous system (CNS) commonly diagnosed in adults, is being recognized increasingly in children. An estimated 1.7%-5.6% of all patients with MS have clinical symptoms before reaching the age of 18 years. In comparison with adults, the diagnosis of MS in children can be more difficult, being dismissed or misdiagnos...

In this review the most important aspects of pediatric multiple sclerosis are presented and compared with the adult form. Some findings appear peculiar of pediatric MS: a. Clinical manifestations are similar in adolescents and adults with MS, however in very young subjects MS frequency at onset is similar in males and females, with a higher frequency of brainstem/cerebellar involvement and acut...

Presence of Candida spp. in infants oral cavity and its association with early childhood caries Fabíola Galbiatti de Carvalho 1* Thaís Manzano Parisotto 2** Josimeri Hebling 3* Luis Carlos Spolidorio 3*** Denise Madalena Palomari Spolidorio 3*** 1DDS, MS, Graduate Student 2DDS, Graduate Student 3DDS, MS, PhD Professor * Department of Orthodontics and Pediatric Dentistry, Araraquara Dental Schoo...

Background: The immunopathogenesis of pediatric multiple sclerosis (MS) is not well understood. Methods: We studied the cytokine profile in pre-treatment serum specimens of 19 pediatric MS patients, 25 adult MS patients, and 22 ageand gender-matched pediatric healthy controls. In addition to IL-2, IL-12p40, IL-12p70, IL-18, IL-23, IL-6, TNF-α, TGF-β-1, IFN-γ, IL-17A, IL-21, IL-10, IL-4, IL-5, I...

(1.2) but increases to 4.2 when age at onset is 13–15 years [3] . The loss of locomotor function, as measured by the Expanded Disability Status Scale, takes longer from the time of first attack in pediatricversus adult-onset MS, but pediatric patients reach disability milestones at a younger age than their adult counterparts. Comparative magnetic resonance imaging (MRI) studies have shown a hig...

Investigators from Washington University School of Medicine and University of Florida College of Medicine, report that susceptibility-weight imaging (SWI) may be useful in differentiating initial presentation of pediatric multiple sclerosis (MS) from acute disseminated encephalomyelitis (ADEM).