Use of cytokines as biomarkers for disease is getting more widespread. Cytokines are conveniently determined by immunoassay, but interference from present antibodies is known to cause problems. In rheumatoid arthritis (RA), interference of rheumatoid factor (RF) may be problematic. RF covers a group of autoantibodies from immunoglobulin subclasses and is present in 65-80% of RA patients. Partly...

Abstract Purpose To prepare stable sustained-release (SR) pellets, containing high ibuprofen (IBU) loading, by hot-melt extrusion (HME) technique using polyethylene glycol 6000 (PEG 6000) and glyceryl monostearate (GMS). Methods HME pellets (60% w/w IBU) were prepared PEG 6000, GMS, mixture of both polymers (1:1). Stability studies performed under stress conditions (40 °C relative humidity “RH”...

Objective: The aim of the present study was to develop and evaluate the monolithic osmotic tablet (MOT) composed of the solid dispersion of ketoprofen (KETO), a poorly water-soluble drug. Solid dispersion technique is generally used for immediate release, as this maximizes the amount of drug absorbed. Sustained release may be obtained by combining solid dispersion technique with MOT so as to in...

Introduction: The Papuan people have utilized the native herb Laportea decumana (Roxb.) Wedd for centuries to treat aches and pains L. is used by attaching leaves to the body area with illness. Methods: This study aimed test optimal composition of PEG 400 and 6000 in L.decumana  simplicia ointment formula produce a good ...

The Leuconostoc species require sucrose in the culture medium as an inducer for the elaboration of glucosyltransferase (GTF) and glucans. Among all the reported putification methods, polyethylene glycol (PEG) is a effective and single step purification method for GTF from Leuconostoc mesenteroides. The extracellular GTFs from Leuconostoc mesenteroides L.m.28 and mutant Leuconostoc mesenteroides...

The effect of salt and drought stress at the water potentials of-2, -4,-6and -8 bars induced by NaCl and PEG 6000 (Polyethylene glycol 6000) each, on germination and early seedling growth, were investigated for two varieties (PU-19 and Type-9). Electrical conductivity (EC) value of the NaCl solutions were 4.5, 8.8, 12.7 and 16.3 dS m(-1). Germination percentage, root and shoot length, and seedl...

Background Microparticles are one of drug delivery systems designed for sustained and controlled release drugs a long period time. Clotrimazole is broad-spectrum antifungal agent, which generally used treatment Candida albicans others fungal infections. Objective The present study aims to fabricate microparticles using beeswax (lipophilic coating) polyethylene glycol (hydrophilic coating). Meth...

Drought stress is a major constraint affecting growth and yield of several economic crops including mungbean [Vigna radiata (L.) Wilczek]. In vitro selection for drought tolerance an alternative method early determination tolerant plants. The objective this study was to perform in genotypes under water induced by polyethylene glycol (PEG) 6000. Seeds 18 were germinated Murashige Skoog (MS) liqu...

Shape memory polyurethanes (SMPUs) are typically synthesized using polyols of low molecular weight (MW~2,000 g/mol) as it is believed that the high density of cross-links in these low molecular weight polyols are essential for high mechanical strength and good shape memory effect. In this study, polyethylene glycol (PEG-6000) with MW ~6000 g/mol as the soft segment and diisocyanate as the hard ...

Aceclofenac is an analgesic and anti-inflammatory agent used in the management of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. The objective of the present work was to investigate the effect of different types of carriers such as polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG) 6000 and sodium lauryl sulphate (SLS) as solubilizer on in vitro dissolution of aceclofenac....