نتایج جستجو برای: peg400
تعداد نتایج: 97 فیلتر نتایج به سال:
Polydimethyl siloxane (PDMS)–glass microchip has a very strong surface effect on polymerase chain reaction (PCR), leading to a very poor PCR yield. In the work reported here, practical dynamic passivation of surfaces of PDMS–glass microchip using polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) was achieved using a conventional thermocycler. The passivation procedure was cost-effective a...
The magnetic relaxation of nanoparticles (MNPs) has been used as a potential heating agent for hyperthermia treatment (MHT). This requires an understanding the mechanism MNPs, such Néel relaxation; however, few studies about using low-frequency AC field have reported. study attempts to clarify correlation between dominance in fields and properties. Nanoparticles Ni0.8Zn0.2Fe2O4 coated with poly...
Targeted delivery of anticancer drugs to tumors has attracted considerable research interest because of its potential to reduce adverse toxicity while improving therapeutic efficacy. In this study, we synthesized and evaluated the therapeutic efficacy of a conjugate of a high-affinity peptide (aptide) and the anticancer drug docetaxel (DTX). A fibronectin extra domain B (EDB)-specific aptide (A...
SR13668, an orally active Akt pathway inhibitor, has demonstrated cancer chemopreventive potential in preclinical studies. To accelerate the clinical development of this promising agent, we designed and conducted the first-ever phase 0 chemoprevention trial to evaluate and compare the effects of food and formulation on SR13668 bioavailability. Healthy adult volunteers were randomly assigned to ...
Polyglycerol dendrimers (PGDs) with 4-5 generations were synthesized and used to investigate the effect of dendritic architecture and its generation on aqueous solubilization of paclitaxel (PTX), a poorly water-soluble drug. Chemical and physical properties of the PGDs were characterized by NMR, MALDI-TOF mass, GPC, viscosity, and dynamic light scattering measurements. The PTX solubility in all...
AIMS The misfolding and the aggregation of specific proteins are key features of neurodegenerative diseases, specifically Transmissible Spongiform Encephalopathies (TSEs). In TSEs, neuronal loss and inflammation are associated with the accumulation of the misfolded isoform (PrP(sc)) of the cellular prion protein (PrP(c)). Therefore we tested the hypothesis that augmenting a natural anti-inflamm...
Enhancement of Solubility of Poorly Water Soluble Drugs Diclofenac Sodium by Mixed Solvency Approach
Enhancement of solubility is one of the difficult tasks which become challenges in formulation development of orally administered drug with poor aqueous solubility. Poor water solubility of drugs often causes significant problems in producing formulations of sufficiently high bioavailability, preventing effective use of the drugs. 'Mixed-solvency ' concept is the phenomenon to increase the solu...
در این پروژه ابتدا مونومر l-لوسین انیدرید (laa) به روش های متداول و سبز تهیه شد. سپس یکسری پلی (آمید- اتر- اوره- یورتان) های (paeuu) فعال نوری جدید بر پایه laa و 4 ، 4- متیلن - بیس (4- فنیل ایزوسیانات) (mdi) و پلی اتیلن گلیکول (peg) سنتز و شناسایی شدند و اثر برخی متغیرهای واکنش و عوامل ساختاری بر ویژگی های فیزیکی آنها مورد مطالعه قرار گرفت. در ابتدا مونومر laa از واکنش حلقه زایی اسیدآمینه l- ...
A chemoenzymatic approach for the synthesis of ?-N-heterocyclic ethyl- and phenylacetamides, levetiracetam analogs, is described. Eight nitrile substrates were prepared through N-alkylation heterocycles (2-pyrrolidinone, 2-piperidinone, 2-oxopiperazine 1-methylpiperazine) directly from hydroxyl group ethyl phenyl ?-hydroxynitriles with yield 35?71% after 12 h. Twenty hydratases (NHases) screene...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید