To understand plant evolution and diversification, information regarding chromosome number meiotic behavior is imperative. The present study was carried out to determine the count, behavior, pollen fertility, seed set of a medicinally important Peganum harmala. Two cytotypes, diploid tetraploid are growing in western Himalaya; cytotype (2n=2x=24) Kashmir Himalaya, (2n=4x=48) Trans Ladakh. Chrom...

Background and Objective: Peganum harmala is a medicinal plant that has been used for treatment of numerous diseases including viral, bacterial and parasitic infections. Anti-proliferative and anti-tumor effects of Peganum harmala extracts and its derivatives have been reported. In the present study, cytotoxic effect of Peganum harmala seeds aquaous extract on leukemic U937 and Molt-4 cells was...

The title compound, C(11)H(13)N(2)O(+)·Cl(-)·2H(2)O, the dihydrate of (+)-vasicinol hydro-chloride, is a pyrrolidinoquinazoline alkaloid. It was isolated from the ethyl acetate fraction of the leaves of Peganum harmala L. The pyrrolidine ring has an envelope conformation with the C atom at position 2 acting as the flap and the C atom at position 3, carrying the hydroxyl substituent, has an S co...

This study was conducted to determine the effects of Artemisia sieberi extract (0.2%, 0.4%, and control) on germination, some morphological characteristics, photosynthesis pigments, and nutrients uptake of Peganum harmala. Results showed that the extract of A. sieberi had a significant effect on seed germination and morphological characteristics of P. harmala. The highest seed germination was c...

objective: peganum harmala (p. harmala), “espand” in persian, has small seeds and has been used in traditional medicine as emmenagogue and an abortifacient. it has various pharmacological effects such as antifungal, antibacterial, hypothermic, anticancer, antinociceptive, and reversible monoamine oxidase inhibition. case details: this case was a 45 years old woman who ingested about 50 grams se...

ETHNOPHARMACOLOGICAL RELEVANCE Peganum harmala is used in traditional medicine to treat a number of diseases including cancer. Our preliminary studies show that the alkaloidal extract of PH seed is cytotoxic to several tumor cell lines in vitro and has antitumor effect in a tumor model in vivo. The present investigation was aimed at extending our previous studies in identifying the components i...

UNLABELLED BACKGROUND Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with fungal and plant cell culture. RESULTS Biotransformation of (-)-ambrox (1) w...

parkinson’s disease is one of the most common neurodegenerative disorders.  there are many documents about the effects of oxidative stress in parkinson’s disease etiology. angiotensin ii activates nadph dependent oxidases and causes superoxides formation.  peganum harmala l. extract, which has angiotensin converting enzyme (ace) inhibitory effect, is considered to evaluate oxidative stress inhi...