Brain metastases are common in patients with NSCLC and represent an evolving treatment area. This is particularly relevant targetable oncogenic drivers for whom CNS penetrant therapies exist. The development of next generation TKIs such as osimertinib, alectinib others, has allowed TKI alone or combination radiation. A significant challenge clinical practice how to utilize these two modalities ...

Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and mechanisms underlying cellular dysfunction are poorly understood. We found that toxic lipids relevant to three different LSDs disrupt multiple lysosomal and other cellular functions. Unbiased drug discovery revealed several structurally distinct protective compounds, approved for other uses, that prevent lysoso...

The National Cancer Institute estimates that 12% of all women (about 1 in 8) will be diagnosed with breast cancer and 3% will be diagnosed with ovarian cancer throughout their lifetime.1,2 5-10% of all breast and ovarian cancers diagnosed are hereditary. Risk factors for hereditary breast and ovarian cancers include a family history with highly penetrant mutations in genes such as BRCA1 and BRC...

The Hellenic Aerospace Industry NDI facility performs Penetrant and Magnetic particles process control operations (daily, weekly, monthly, quarterly) to ensure the performance of the in-use materials. Taking into consideration that all penetrant materials shall conform to the requirements of SAE AMS 2644 and all magnetic particles materials shall conform to SAE AMS 3044 or SAE AMS 3045 or SAE A...

Heterozygosity probabilities P(het) for relatives of isolated cases produced by incompletely penetrant autosomal dominant genes and recurrence risks for their offspring, R = P(het).K/2, where K is the penetrance value, have been calculated in the literature for some simple particular situations. Bayes theorem and elements from the theory of finite difference equations enabled us to derive the h...