Insulin-loaded microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant. The pseudoternary phase diagrams were constructed to determine the composition of microemulsions. The insulin permeation flux of microemulsions containing oleic acid as oil phase through excised mou...

The mechanism of clearance of circulating fibrin monomer was investigated in rabbits through (1) study of decay in plasma concentrations of 125I-labeled monomers with variant fibrinopeptide content and (2) concurrent analysis of decay of the monomers relative to coinjected 131I-fibrinogen. Under the conditions employed, essentially all of the fibrin became distributed in a soluble form in plasm...

The impermeability of defect-free graphene to all gases has been recently contested since experimental evidence (see Nature 579, 229–232 (2020)) hydrogen transmission through a two-dimensional carbon layer obtained. By means density functional theory computations here we elucidate flipping mechanism which involves the insertion chemisorbed atom in middle C–C bond via transition state that is re...