he benzodiazepines are the second group of drugs used by anesthetists that could truly be called "multipurpose," the first being the phenothiazines. The most popular of the latter, chlorpromazine, is known by the trade name Largactil in Europe, indicating the multiplicity of fields in which it can be used. While the phenothiazines were the more versatile of the two, they were also the more toxi...

Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their precursor in the world of natural compounds. Apart from their fundamental neuroleptic action connected with the dopaminergic receptors blockade, phenothiazine derivatives also exert diverse biological activities, which account for their cancer chemopreventive-effect, as: calmodulin- and protein kinase C ...

The effects of three phenothiazines, chlorpromazine (CPZ), chlorpromazine sulfoxide (CPZ-O), and 74iydroxychlor promazine (7-OH-CPZ), on the growth of B-16 and HardingPassey mouse melanomas were investigated. CPZ and 7-OH-CPZ both inhibited tumor growth, but CPZ-O did not. The melanoma tyrosinase was activated by CPZ both in vivo and in vitro. There was no significant effect of CPZ on the succi...

Multidrug-resistant Mycobacterium tuberculosis (MDRTB) and antibiotic-resistant Plasmodium falciparum are the major global lethal infections accounting for over 4 million deaths per year. Methicillin-resistant Staphylococcus aureus (MRSA) is the major global nosocomial infection and resistance to vancomycin is evident and may become common. This review provides the scientific and medical basis ...

A novel double hetero[4]helicene consisting of two phenothiazines (1) has been synthesized. The racemization barrier of 1 is high enough for optical separation. We successfully obtained the single crystals of the radical cation salt of 1˙(+), whose torsion angles were decreased compared to those of the neutral state.

The review is devoted for the solid phase extraction and the extractive spectrophotometric methods for the determination of some psychotropic drugs, e.g. phenothiazines, thioxanthenes, dibenzothiazines, fluoxetine, fluvoxamine, trazodone.