Abnormal aldosterone physiology has been implicated in the pathogenesis of cardiometabolic diseases. Single aldosterone measurements capture only a limited range of aldosterone physiology. New methods of characterizing aldosterone physiology may provide a more comprehensive understanding of its relationship with cardiometabolic disease. We evaluated whether novel indices of aldosterone response...

Theta (6-12 Hz) field potentials and the synchronization (coherence) of these potentials present neural network indices of hippocampal physiology. Theta signals within the hippocampal formation may reflect alterations in sensorimotor integration, the flow of sensory input, and/or distinct cognitive operations. While the power and coherence of theta signals vary across lamina within the septal h...

INTRODUCTION Cancer is a complex disorder whose detection and monitoring remains challenging. A biological modeling system, the biology of functions (BoF), claims to be able to evaluate physiologic elements related to carcinogenic activity. A pilot study was undertaken to evaluate the accuracy of the BoF in detecting differences between cancer cases and matched controls. MATERIALS AND METHODS...

considering the emphasis of islam on the importance of fasting, muslims attempt to fast from dawn until sunset during the holy month of ramadan. fasting is associated with several benefits for normal and healthy individuals. however, it could pose high risks to the health of diabetic patients due to certain physiological changes. this study aimed to compare the physiological changes associated ...

labor is a physiological event involving a sequential, integrated set of changes within the myometrium, deciduas, and uterine cervix that occur gradually over a period of days to weeks. biochemical connective tissue changes in the uterine cervix appear to precede uterine contractions and cervical dilation, and all of these events usually occur before rupture of the fetal membranes. in other wor...

F ractional flow reserve (FFR) is an intracoronary pressure-derived index that circumvents many of the limitations of angiography in assessing stenosis severity. 1 From a broad perspective , the greatest achievement of the investigators from Aalst, Eindhoven, and Houston who developed FFR was incorporating intracoronary physiology to routine clinical practice. Key elements in FFR success were (...

The prevalence of obesity and type 2 diabetes increases with age. Despite this, few studies have examined these conditions simultaneously in aged animals, and fewer studies have measured the impact of these conditions on brain function. Using an established animal model of brain aging (F344 rats), we investigated whether a high-fat diet (HFD) exacerbates cognitive decline and the hippocampal ca...