This prospective study was designed to compare the captopril suppression test with the salt-loading approach to confirm the diagnosis of primary aldosteronism. A total of 49 patients were referred with a presumed diagnosis of primary aldosteronism. The captopril test was performed in the morning with patients in the seated position after overnight fasting. Blood samples for plasma aldosterone w...

Abnormalities in aldosterone secretion are unusual in Cushing's syndrome even in the presence of hypokalemic alkalosis (1). Similarly, increased cortisol excretion is not seen in primary aldosteronism (2-7). Little information regarding corticosterone secretion is available in either condition. Increased excretion of corticosterone metabolites has been suggested in several cases of primary aldo...

Urinary exosomes are vesicles derived from renal tubular epithelial cells. Exosomes often contain several disease-associated proteins and are thus useful targets for identifying biomarkers of disease. Here, we hypothesized that the phosphorylated (active) form of the sodium chloride cotransporter (pNCC) or prostasin could serve as biomarkers for aldosteronism. We tested this in 2 animal models ...

BACKGROUND Primary aldosteronism is the leading cause of secondary hypertension, the management of this disease requiring an interdisciplinary approach. OBJECTIVES Evaluation of evolutionary features of patients with secondary hypertension and primary aldosteronism. METHODOLOGY We have followed 26 patients diagnosed with secondary hypertension and primary aldosteronism, who were admitted co...

Aldosteronism is a rare complication of pregnancy. We report a case of a 26-year-old woman who became pregnant soon after a diagnosis of primary aldosteronism due to left adrenal adenoma was made. Only oral potassium supplementation was required in addition to routine prenatal care until 36 weeks' gestation. Subsequently, antihypertensive medication was needed to control elevated blood pressure...

Primary aldosteronism (autonomous aldosterone production with suppressed renin) plays an important pathophysiological role in what has been previously labeled as essential hypertension. Besides the recently described germline mutations in the KCNJ5 potassium channel associated with familial primary aldosteronism, somatic mutations in the same channel have been identified within aldosterone-prod...