conclusions the lack of difference between adma levels in patients with pa and eh suggests that endothelial dysfunction is more likely related to hypertension per se than to the specific etiology of elevated blood pressure. results patients with pa had significantly higher concentrations of adma than healthy controls (0.488 ± 0.085 vs. 0.433 ± 0.053 μmol/l, p = 0.027). no difference was found i...

 Abstract A 26 -year- old woman presented with rhabdomyolysis secondary to severe hypokalemia. Hypertension and metabolic alkalosis could lead to the suspicion of primary aldosteronism, which was confirmed by a decreased plasma rennin, elevated plasma aldosterone levels and high aldosterone/rennin ratio additionally. Additionally adrenal computed tomography showed an adrenal tumour. Blood press...

Primary aldosteronism is the most common cause of secondary hypertension. In the past, screening for primary aldosteronism was offered only in patients with hypertension associated with hypokalemia. Recent studies showed that hypokalemia is seen in only 25% of the patients with primary aldosteronism, which has increased the prevalence of primary aldosteronism to 10-15% of all cases with new ons...

abstract a 26 -year- old woman presented with rhabdomyolysis secondary to severe hypokalemia. hypertension and metabolic alkalosis could lead to the suspicion of primary aldosteronism, which was confirmed by a decreased plasma rennin, elevated plasma aldosterone levels and high aldosterone/rennin ratio additionally. additionally adrenal computed tomography showed an adrenal tumour. blood pressu...

HomeHypertensionVol. 77, No. 3Primary Aldosteronism Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessEditorialPDF/EPUBPrimary AldosteronismThree Strikes and Out John W. Funder FunderJohn Correspondence to: Funder, Hudson Institute of Medical ...

abstract a 26 -year- old woman presented with rhabdomyolysis secondary to severe hypokalemia. hypertension and metabolic alkalosis could lead to the suspicion of primary aldosteronism, which was confirmed by a decreased plasma rennin, elevated plasma aldosterone levels and high aldosterone/rennin ratio additionally. additionally adrenal computed tomography showed an adrenal tumour. blood pressu...

This study reports the determination of plasma 18-hydroxycortisol (18-OHF) using a new and easy enzyme-linked immunosorbent assay (ELISA) method in primary aldosteronism and compares the values found in essential hypertensives and normotensive controls. In primary aldosteronism, we evaluated usefulness of plasma 18-OHF determination and the dexamethasone suppression test in the diagnosis of glu...

Primary aldosteronism is an adrenal abnormality in which there is an excessive production of aldosterone above that required for electrolyte homeostasis which is not driven by known stimulators of aldosterone secretion, although these may retain some degree of modulatory activity on aldosterone secretion. In the early years following the description of primary aldosteronism, the etiology was as...

BACKGROUND A published clinical prediction score indicated that a unilateral adrenal adenoma and either hypokalemia or an estimated glomerular filtration rate of 100 ml/min/1.73 m2 was 100% specific for unilateral primary aldosteronism. This study aimed to validate this score in a separate cohort of patients with primary aldosteronism. METHODS A review of patients with primary aldosteronism f...