Clinical trials have established the benefit of androgen deprivation therapy (ADT) combined with radiotherapy in prostate cancer. ADT sensitizes prostate cancer to radiotherapy-induced death at least in part through inhibition of DNA repair machinery, but for unknown reasons, adjuvant ADT provides further survival benefits. Here, we show that androgen receptor (AR) expression and activity are d...

AIM To retrospectively investigate the biochemical outcome following delayed radiotherapy in patients with prostate cancer. PATIENTS AND METHODS From July 2000 to November 2008, 144 consecutive patients with localized prostate cancer underwent radiotherapy and androgen-deprivation therapy. Biochemical progression-free survival was compared in patients who began radiotherapy >6 months (delayed...

The increased frequency of PSA testing has led to an increased diagnosis of early organ confined prostate cancer. Diagnosis is primarily made by histology, via TRUS-guided sextant biopsy or template biopsy which can provide improved localisation of cancer within the prostate. Staging is from digital rectal examination, from imaging with multi-parametric MRI (TNM staging), from PSA levels, and f...

Prostate cancer is the one of the most commonly diagnosed cancer among men throughout the world. In the recent days, prostate cancer can be managed by several options such as surgery, chemotherapy, radiotherapy, etc. Radiotherapy is considered as one of the popular options to treat prostate cancer due to excellent survival rate and fewer side effects. The field of radiotherapy is evolving since...

RODRIGUES G. Is intensity-modulated radiotherapy for prostate cancer ready for prime-time? Can J Urol 2012;19(4):6381-6382. the therapeutic ratio between the positive anticancer effect of radiotherapy on macroscopic and microscopic disease and the negative normal tissue effects leading to both acute and late radiotherapy toxicities. In the context of prostate cancer radiotherapy, these technolo...

We investigated whether statin use is associated with reduced risk of recurrence in prostate cancer patients who undergo radiotherapy. A retrospective cohort of 774 patients from a California health plan was followed for 5 years. Statin use prior to, during and after radiotherapy was not associated with prostate cancer recurrence [hazard ratio=0.99 (0.70-1.39), 0.87 (0.62-1.22) and 0.78 (0.55-1...

Small cell carcinoma of the prostate (SCCP) is rare in clinical practice. It is often accompanied with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present a case of SCCP with SIADH that was successfully treated with radiotherapy in the metastatic lymphnodes and prostate. The patient was an 81-year-old male with a castrate-resistant prostate cancer (CRPC) with invade...

introduction: multiple fields and presence of heterogeneities create complex dose distributions that need three dimensional dosimetry. in this work, we investigated mr-based magic gel dosimetry as a three-dimensional dosimetry technique to measure the delivered dose to bladder and rectum in prostate radiation therapy. materials and methods: a heterogeneous slab phantom including bones was made....

Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer related mortality. Localized prostate cancer is treated by either radical pros‐ tatectomy or radiotherapy. Low levels of testosterone have been associated with prostate cancer progression. These tumor presented advanced tumor stage, high Gleason scores, and had significantly worse overall surviva...

Intrafractional motion of the prostate can be significant, and its management is of particular importance for hypofractionated regimes and stereotactic ablative radiotherapy (SABR). In this paper, we describe the Clarity Autoscan with Monitoring system and its use of non-invasive soft tissue imaging to monitor prostate motion during the course of radiotherapy. The system uses a 4D autoscan ultr...