background: hearing loss (hl) is the most frequent neurosensory impairment. hl is highly heterogeneous defect. this disorder affects 1 out of 500 newborns. this study aimed to determine the role of dfnb2 locus and frequency of myo7a gene mutations in a population from west of iran. methods: thirty families investigated in shahrekord university of medical sciences in 2014, genetic linkage analys...

We have developed a set of graph theory-based tools, which we call Comparative Analysis of Protein Domain Organization (CADO), to survey and compare protein domain organizations of different organisms. In the language of CADO, the organization of protein domains in a given organism is shown as a domain graph in which protein domains are represented as vertices, and domain combinations, defined ...

The analysis of protein domains has gained considerable attention over the last years. Many new insights on protein modular evolution, combined with improved domain detection, have paved the way for an integrated analysis of protein families from a domain-centric perspective. We recently released DoMosaics, a JAVA application that facilitates the interactive analysis of protein domain arrangeme...

micronemes are secretory organelles of the invasive stages of apicomplexan parasites and contain proteins that are important for parasite motility and host cell invasion. even though coccidiosis is a complex disease that can be caused by any combination of mainly seven species, most of the molecular researches concerning characterization of host and parasite genes and proteins have been limited...

in this work, time domain analysis is used to solve adler’s equation in order to obtain the required time, for an oscillator under external injection, reaching the steady-state condition. mathematical approach has been applied to fully describe the transient of frequency acquisition in injection-locked lc and ring oscillators considering their time-varying nature. then, the analysis is verified...

In this study, we mined the PDB and created a structural library of 178,465 interfaces that mediate protein–protein/domain–domain interactions. Interfaces involving same CATH fold(s) were clustered together. Our analysis reveals similarities between chain–chain domain–domain The also illustrates how single protein fold can interact with multiple folds using similar interfaces. is hence useful r...

Many methods have been proposed for inference of protein-protein interactions from protein sequence data. This chapter focuses on methods based on domain-domain interactions, where a domain is defined as a region within a protein that either performs a specific function or constitutes a stable structural unit. In these methods, the probabilities of domain-domain interactions are inferred from k...