objective(s):several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. however, the precise regulation mechanism is still not clear. this study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (nheks) and to explore the...

The ErbB RTKs (EGFR, HER2, HER3, and HER4) have been well-studied in cancer. EGFR, HER3 stimulate cancer proliferation, principally by activating the phosphatidylinositol-3-kinase extracellular signal-regulated kinase (ERK) pathways, resulting increased cell survival proliferation. Cancer cells high densities of causing phosphorylation tyrosine amino acids on protein substrates near C-terminal ...

Background: Recently, it has been revealed that tyrosine kinase inhibitors (TKIs) act through inducing both oxidative and endoplasmic reticulum (ER) stress in chronic myeloid leukemia cells. However, ER stress signaling triggers both apoptotic and survival processes within cells. Nevertheless, mechanisms by which TKIs avoid the pro-survival effects are not clear. The aim of this study was to ev...

how to cite this article: fallah e, arman a, najafi m, shayegh b. effect of tamoxifen and lithium on treatment of acute mania symptoms in children and adolescents. iran j child neurol. spring 2016; 10(2):16-25. abstract objective many studies have supported the role of protein kinase c (pkc) inhibitors in the physiopathology and treatment of bipolar disorder in adults. tamoxifen is one of the d...

Recently we reported that the pyridinylimidazole class of p38 mitogen-activated protein (MAP) kinase inhibitors potently inhibited the facilitated transport of nucleosides and nucleoside analogs in K562 cells. These compounds competed with the binding of nitrobenzylthioinosine (NBMPR) to K562 cells, consistent with inhibition of the NBMPR-sensitive equilibrative transporter (ENT1). In this stud...