Quaternary prevention is the prevention of unnecessary medicine or the prevention of overmedicalisation. The principle of “primum non nocere” is central to the whole of medicine. The task to avoid excess medical interventions is particularly mandatory in the field of general practice. We report on a workshop on this topic held at the 15th Wonca Europe Conference in Basel, in September 2009. In ...

We stand at the brink of a fundamental change in how medicine will be practiced. Over the next 5-20 years medicine will move from being largely reactive to being predictive, personalized, preventive and participatory (P4). Technology and new scientific strategies have always been the drivers of revolutions and this is certainly the case for P4 medicine, where a systems approach to disease, new ...

In this article, we define a new class of graphs, the fat-extended P4-laden graphs, and we show a polynomial time algorithm to determine the Grundy number of the graphs in this class. This result implies that the Grundy number can be found in polynomial time for any graph of the following classes: P4-reducible, extended P4-reducible, P4-sparse, extended P4-sparse, P4-extendible, P4-lite, P4-tid...

background: the purpose of the study was to evaluate the role of progesterone/ estradiol (p4/e2) ratio as a predictive tool for clinical pregnancy in art cycles with a premature progesterone rise of >1.5 ng/ml on the day of human chorionic gonadotropin (hcg) trigger. methods: retrospective analysis was done on 569 fresh embryo transfer cycles from january 2011 to december 2012 at the infertilit...

Abstract Introduction: Omega 3 fatty acid especially in the form of fish oil, has structural and biological role in the body's various systems especially nervous system. Numerous studies have tried to research about it. Auditory is one of the affected systems. Omega 3 deficiency can have devastating effects on the nervous system and auditory. This study aimed to evaluate neural conduction in n-...

The discovery of progesterone (P4) and elucidation of the mechanisms of P4 action have an important place in the history of endocrinology and reproduction. Circulating P4 concentration is determined by a balance between P4 production, primarily by the corpus luteum (CL), and P4 metabolism, primarily by the liver. The volume of luteal tissue and number and function of large luteal cells are prim...