Radiobiological researches with heavy ions have been started at ITEP in 2006 on unique heavy ion accelerating facility ITEP-TWAC. The main purpose of these researches is study of the biological efficiency of carbon ions for different types of biological objects, such as tumor and normal cells, in the framework of the development of heavy ion therapy for cancer treatment in Russia. Another possi...

The present thesis is focused on the development and application of dose response models for radiation therapy. Radiobiological models of tissue response to radiation are an integral part of the radiotherapeutic process and a powerful tool to optimize tumor control and minimize damage to healthy tissues for use in clinical trials. Ideally, the models could work as a historical control arm of a ...

The objective of microdosimetry was, and still is, to identify physical descriptions of the initial physical processes of ionising radiation interacting with biological matter which correlate with observed radiobiological effects with a view to improve the understanding of radiobiological mechanisms and effects. The introduction of therapy with particles starting with fast neutrons followed by ...

Introduction: The current study aimed to compare the performance of radiobiological models in predicting acute esophagitis (AE) complications after three-dimensional conformal radiation therapy (3D-CRT). Material and Methods: Out of a total of 100 patients, 50 patients with concurrent chemotherapy and 50 patients without such therapy wer...

PURPOSE To review current opinion on the production and temporal evolution of low-LET radiobiological damage. METHODS Standard cell survival models which model repair/misrepair kinetics in order to quantify dose-response relations and dose-protraction effects are reviewed and interrelated. Extensions of the models to endpoints other than cell survival, to multiple or compound damage processin...

"Biological optimization" (BIOP) means planning treatments using (radio)biological criteria and models, that is, tumour control probability and normal-tissue complication probability. Four different levels of BIOP are identified: Level I is "isotoxic" individualization of prescription dose D(presc) at fixed fraction number. D(presc) is varied to keep the NTCP of the organ at risk constant. Sign...

diation and radiobiological researches and radiation protection. The first two lines are included in the Topical Plan for Scientific Research of JINR and were concentrated on: • neutron spectrometry and radiometry, radiation monitoring; • investigation of radiation fields around thick targets; • physical support of radiobiological experiments; • shielding calculations and design; • investigatio...