The metabolism of tresperimus, a new immunosuppressive agent, was investigated in vivo and in vitro in rat and in human. Two metabolic pathways were identified at each side of the molecule with two deamination reactions on the spermidine moiety and hydrolysis of the amide bond leading to the liberation of guanidinohexylamine. As the major metabolic pathway of the drug seemed to be the oxidative...

The biliary excretion and blood/plasma ratios of four novel 5-bromo-6-alkoxy- 5,6-dihydro prodrugs to S-ethyl-2'-deoxyuridine (EDU) including (-)-trans-(5S, 6S)-S-bromo-S-ethyl-6-methoxy-S, 6-dihydro-2'-deoxyuridine (BMEDU), (+ )-trans( SR, 6R)-S-bromo-S-ethyl-6-ethoxy-S, 6-deoxyuridine (BEEDU), (+ )-trans-(SR, 6R)-5-bromo-5-ethyl-6-ethoxy -S, 6-dihydro-S '-O-valeryl-2 ':.deoxyuridine (VBE...

objective: achillea millefolium (a. millefolium) is known as an orexigenic herb in iranian traditional medicine. in this study, the possible orexigenic effect of hydro-alcoholic extract of a. millefolium was investigated by measuring plasma ghrelin level.materials and methods: thirty male wistar rats were divided into five groups. control group received water. treatment groups received 50, 100 ...

the biliary excretion and blood/plasma ratios of four novel 5-bromo-6-alkoxy- 5,6-dihydro prodrugs to s-ethyl-2'-deoxyuridine (edu) including (-)-trans-(5s, 6s)-s-bromo-s-ethyl-6-methoxy-s, 6-dihydro-2'-deoxyuridine (bmedu), (+ )-trans( sr, 6r)-s-bromo-s-ethyl-6-ethoxy-s, 6-deoxyuridine (beedu), (+ )-trans-(sr, 6r)-5-bromo-5-ethyl-6-ethoxy -s, 6-dihydro-s '-o-valeryl-2 ':.de...

Francisella tularensis, a highly infectious bacterium, is the causative agent of Tularemia (rabbit fever). Categorized by Center for Disease Control and Prevention as Category A bioterrorism agent, tularensis highest level concern. Previously, we identified that dillapiole, compound extracted from fennel, dampens F. virulence gene expression. While having no apparent effect on viability treatme...