The Robert W. Berliner Award for Excellence in Renal Physiology recognizes distinguished lifetime achievement in renal physiology research. This year’s recipient is Roland C. Blantz, M.D., of the University of California, San Diego (UCSD). Dr. Blantz was honored at the 2017 Renal Dinner and participated in the Renal Section’s Posters and Professors Reception at EB 2017 in Chicago, Illinois. Bor...

Nutritional and botanical approaches that may benefit small animals diagnosed with renal disease are considered with regard to their effects on renal physiology and ability to ameliorate specific pathologies. Suggestions are made for water- and fat-soluble vitamins, mushrooms, quercetin, and Western and Chinese herbs, based on their activities as free-radical scavengers, immune modulators, anti...

Introduction With this issue, CJASN begins a new series of review articles designed to reconnect clinical nephrologists and trainees with the fundamentals of renal physiology and pathophysiology. For many of us, our initial interest in nephrology was the result of fascination with clinical fluid and electrolyte disturbances and fascination with the intricate underlying pathophysiologic mechanis...

The kidney has a high energy demand and is dependent on oxidative metabolism for ATP production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is a common denominator for several renal diseases. While the mitochondrial master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is highly expressed in kidney, its role in renal physiology...

Abstract Introduction Apelin is a vasoactive peptide isolated as a selective endogenous ligand of orphan receptor, APJ, which was genetically identified to have closest identity to the angiotensin II type 1 (AT-1) receptor. Subsequent studies elucidated the roles of the apelin–APJ system in human physiology, including the regulation of cardiovascular function and fluid homeostasis. In spite of ...

Renal function plays a central role in cardiovascular, kidney, and multiple other diseases, and many existing and novel therapies act through renal mechanisms. Even with decades of accumulated knowledge of renal physiology, pathophysiology, and pharmacology, the dynamics of renal function remain difficult to understand and predict, often resulting in unexpected or counterintuitive therapy respo...