Type VII collagen, as a major component of anchoring fibrils found at basement membrane zones, is crucial in anchoring epithelial tissue layers to their underlying stroma. Recently, type VII collagen was discovered in the inner human retina by means of immunohistochemistry, while proteomic investigations demonstrated type VII collagen at the vitreoretinal interface of chicken. Because of its po...

Embryonic retinal neurons lose the ability to extend neurites on laminin-1 (LN-1) with increasing developmental age yet still do so on other laminin isoforms. However, after treatment of LN-1 with antibodies to "short-arm" regions or removal of the short arms proteolytically, LN-1 supports attachment and extension of neurites even by late embryonic retinal neurons. We have mapped a domain for a...

Embryonic chick neural retina cells in culture release complexes of proteins and glycosaminoglycans, termed adherons, which stimulate cell-substratum adhesion when adsorbed to nonadhesive surfaces. Two distinct retinal cell surface macromolecules, a 170,000-mol-wt glycoprotein and a heparan sulfate proteoglycan; are components of adherons that can independently promote adhesion when coated on i...

Objective: To compare the mean changes in central corneal thickness (CCT) and corneal endothelial-cell density (CED) after removal of silicon oil (ROSO) using anterior (limbal) versus posterior (pars plana) approach in aphakic patients following successful retinal re attachment surgery. Study Design: Randomized controlled trial. Place and Duration of Study: Armed Forces Institute of Ophthalmolo...

Degenerative retinal diseases are a leading cause of visual loss and irreversible blindness, particularly in the developed world. Retinal pigment cell (RPE) transplantation is nowadays considered the most promising therapeutic approach for certain retinal diseases, and the presence of a supportive scaffold has been considered essential to ensure the success of the implant. In this work, collage...

Retinal detachment surgery has been considered an inpatient hospital procedure requiring preoperative and postoperative hospitalization. In this pilot study, outpatient retinal detachment surgery was performed on sixteen patients and the results (100% success rate after an average follow-up of 8.3 months) were comparable or better than reported overall success rates for retinal detachment ...

BACKGROUND AND OBJECTIVE To describe clinical features and outcomes of scleral buckle surgery as treatment for patients with rhegmatogenous retinal detachment caused by retinal dialysis. PATIENTS AND METHODS Nonrandomized, consecutive case series. All patients underwent encircling scleral buckle for retinal detachment secondary to retinal dialysis. Visual acuity (VA) and retinal attachment st...