From 2001 to 2004, Switzerland switched from routine vaccination with oral polio vaccine (OPV) to inactivated polio vaccine (IPV), using both vaccines in the intervening period. Since IPV is less effective at inducing mucosal immunity than OPV, this change might allow imported poliovirus to circulate undetected more easily in an increasingly IPV-immunized population. Environmental monitoring is...

The first isolations of B virus were made by Sabin and Wright (1), and independently by Gay and Holden (2), from the central nervous system of an investigator who developed a spreading, fatal infection with ascending myelitis after a bite on the hand from an apparently normal rhesus monkey. Gay and Holden called the agent W virus and thought it to be a highly neurotropic strain of herpes simple...

The National Poliovirus Reference Laboratory at the Victorian Infectious Diseases Reference Laboratory (VIDRL) is responsible for poliovirus testing for Australia and the Pacific Island countries. It is also a regional reference laboratory for the Western Pacific Region of the World Health Organization. Surveillance for acute flaccid paralysis, a clinical manifestation of poliomyelitis, is coor...

A 20-year-old female hypogammaglobulinemic patient received monotypic Sabin 3 vaccine in 1962. The patient excreted type 3 poliovirus for a period of 637 days without developing any symptoms of poliomyelitis, after which excretion appeared to have ceased spontaneously. The evolution of Sabin 3 throughout the entire period of virus excretion was studied by characterization of seven sequential is...

In order to begin to elucidate the genomic basis of the attenuation of mouse-adapted, poliovirus type 2 strain W-2 (PV2/W-2), we have cloned and sequenced the virus and compared it with the virulent, mouse-adapted PV2/Lansing strain. In addition, we have performed computer-generated comparisons of PV2/W-2 to the non-mouse-adapted, attenuated PV2/Sabin strain to determine whether mutational patt...

Circulating Vaccine Derived Poliovirus (cVDPV), is a genetic mutation of the Sabin virus. Sierra Leone reported its last case wild polio virus in 2010. However, December 2020, national disease surveillance program was notified three people with acute flaccid paralysis who had cVDPV2. We investigated to identify source, determine magnitude outbreak and risk factors.

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also associated with serious neurological disorders. An attenuated EV71 strain [EV71(S1-3')] has been established in the cynomolgus monkey infection model; this strain contains the attenuation determinants derived from the type 1 poliovirus vaccine strain, Sabin 1 [PV1(Sabin)], in the 5' nontranslated region (NTR...

An interpolation technique with the capability of local shape control for meshes of arbitrary topology is presented. The interpolation is a progressive process which iteratively updates the given mesh, through a two-phase Doo-Sabin subdivision scheme, until a control mesh whose limit surface interpolates the given mesh is reached. For each iteration of the progression, the two-phase scheme work...