Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea Graduate School of Science and Engineering for Research, University of Toyama, Toyama 930-8555, Japan Faculty of Pharmaceutical Sciences, Nagasaki University, Nagasaki 852-8131, Japan Department of Physiology, The University of Texas Health Scien...

where f(t |Θ) is the probability density of the coalescent time. Assuming free recombination between loci, the full likelihood is a product of each locus likelihood. In order to determine the likelihood we must determine the density f(t |Θ) for coalescent of two samples in the IM model. Wang and Hey (2009) find the time to the MRCA by explicitly integrating over all possible sample paths in the...

Recent statistical and computational analyses have shown that a genealogical most recent common ancestor (MRCA) may have lived in the recent past [Chang, J.T., 1999. Recent common ancestors of all present-day individuals. Adv. Appl. Probab. 31, 1002-1026. 1027-1038; Rohde, D.L.T., Olson, S., Chang, J.T., 2004. Modelling the recent common ancestry of all living humans. Nature 431, 562-566]. Howe...

Chemical differences between mid-ocean ridge basalts (MORBs) and ocean island basalts (OIBs) provide critical evidence that the Earth's mantle is compositionally heterogeneous. MORBs generally exhibit a relatively low and narrow range of (3)He/(4)He ratios on a global scale, whereas OIBs display larger variability in both time and space. The primordial origin of (3)He in OIBs has motivated hypo...

Suspension polymerization process is commonly used to produce expandable polystyrene. In the conventional method for producing this polymer, two different initiators are added to the process at two different temperature levels. In the industrial scale, this process is time consuming and difficult to control. A new method (Multi-Stage Initiator Dosing, MID) is proposed, in which, the initiator i...