نتایج جستجو برای: schistosomicidal drugs
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BACKGROUND Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp. parasite only at the adult stage. HDAC inhibitors (HDACi) such as Trichostatin A (TSA) induce parasite mortality in vitro (schistosomula and adult worms), however the downstream effects of histone hyperacetylatio...
Schistosomiasis is a widespreadd tropical parasitic disease, caused by three species of the blood-fluke Schistosoma. The disease is debilitating and affects 200 million people in tropical areas; the death toll is estimated at two hundred thousands people per year. Schistosomiasis is currently treated with one drug, Praziquantel, whose precise molecular target is unknown. Several other drugs are...
To investigate the nature of the complex formed between DXA and Miracil D (l-diethylaminoethylamino-4-methyl-lOthiaxanthenone, Lucanthone, Nilodin), a series of derivatives of this carcinostatic, schistosomicidal, and bacteriostatic com pound have been examined in three test systems: the growth of intact Bacillus subtilis, the heat-denaturation profile of na tive DNA, and the subcellular DNA-di...
Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose was interruption ...
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