Simulations of electron transport are carried out by solving the Fokker-Planck equation in the diffusive approximation. The system of a single laser hot spot, with open boundary conditions, is systematically studied by performing a scan over a wide range of the two relevant parameters: (1) Ratio of the stopping length over the width of the hot spot. (2) Relative importance of the heating throug...

Cdc25 phosphatases are key activators of the eukaryotic cell cycle and compelling anticancer targets because their overexpression has been associated with numerous cancers. However, drug discovery targeting these phosphatases has been hampered by the lack of structural information about how Cdc25s interact with their native protein substrates, the cyclin-dependent kinases. Herein, we predict a ...

The M26 mutation in the ade6 gene of Schizosaccharomyces pombe creates a hot spot of meiotic recombination. A single base substitution, the M26 mutation is situated within the open reading frame, near the 5' end. It has previously been shown that the heptanucleotide sequence 5' ATGACGT 3', which includes the M26 mutation, is required for hot spot activity. The 510-bp ade6-delXB deletion encompa...

The variable (V) regions of immunoglobulin heavy and light chains undergo high rates of somatic mutation during the immune response. Although point mutations accumulate throughout the V regions and their immediate flanking sequences, analysis of large numbers of mutations that have arisen in vivo reveal that the triplet AGC appears to be most susceptible to mutation. We have stably transfected ...

A stable nanoscale thermal hot spot, with temperature approaching 100 °C, is shown to be sustained by localized Ohmic heating of a focused electric field at the tip of a slender conic nanopore. The self-similar (length-independent) conic geometry allows us to match the singular heat source at the tip to the singular radial heat loss from the slender cone to obtain a self-similar steady temperat...

[1] Here, I present a new absolute plate motion model of the Earth’s surface, determined from the alignment of present-day surface motions with 474 published shear wave (i.e., SKS) splitting orientations. When limited to oceanic islands and cratons, splitting orientations are assumed to reflect anisotropy in the asthenosphere caused by the differential motion between lithosphere and mesosphere....

In parallel systems it is possible for several processors to request concurrent access to a shared data structure such as a synchronization variable. Such an access pattern causes what is known as hotspot contention. In shared-memory multiprocessor systems that use a multistage interconnection network, hot-spot contention may result in "tree saturation" that degrades the system performance. It ...

Traffic arrival processes are the important ingredients for the performance evaluation of ATM switches. Three important aspects of traffic models are the arrival pattern, output address correlation and, output address (or hot-spot) distribution. Here we investigate the relative importance of selfsimilar traffic model vs bursty traffic model, under the various conditions of output addressing, an...

In the context of protein-protein interactions, the term "hot spot" refers to a residue or cluster of residues that makes a major contribution to the binding free energy, as determined by alanine scanning mutagenesis. In contrast, in pharmaceutical research, a hot spot is a site on a target protein that has high propensity for ligand binding and hence is potentially important for drug discovery...

[1] Recent observations of ridge bathymetry suggest magmatic segmentation at fastand intermediatespreading centers is linked to the migration of the spreading axis over the mantle. At fastand intermediatespreading centers, Carbotte et al. (2004) observed that leading segments, those that are offset in the direction of ridge migration, are typically shallower (interpreted to be magmatically robu...