Targeted disruption of the genes for the 5-HT1B and 5-HT2C serotonin receptors and monoamine oxidase A have confirmed pharmacological experiments and revealed unexpected behavioral roles for serotonin.

47 Serotonin initiates various rhythmic behaviors in vertebrates. Previously, we have shown 48 that serotonergic neurons innervate the central vocal pathway in the African clawed frog 49 (Xenopus laevis). We also discovered that exogenous serotonin applied to isolated brains in vitro 50 activates fictive vocalizations by activating 5-HT2C-like receptors. In this study we examined the 51 locatio...

The neurotransmitter serotonin is produced by neurons in the raphe nuclei of the brainstem, which send axonal projections broadly to the cerebral cortex, the amygdala, and other brain regions. The modulation of serotonin neurotransmission appears to be involved in both the pathophysiology and the treatment of depression. For example, serotonin-selective reuptake inhibitors (SSRIs), by blocking ...

Serotonin (5-hydroxytryptamine, 5-HT) can stimulate the lower esophageal sphincter (LES) by indirect actions on the modulation of reflexes and by a direct action on smooth muscles. Aim:of this study was to investigate the role of 5-HT and selective 5-HT receptor subtypes in the regulation of the lower esophageal sphincter (LES) in the rat by measuring electromotor activity of the LES. Methods:T...

ABSTRACT Morphological remodeling of dendritic spines is critically involved in memory formation and depends on adhesion molecules. Serotonin receptors are also implicated this remodeling, though the underlying mechanisms remain enigmatic. Here, we uncovered a signaling pathway involving molecule L1CAM (L1) serotonin receptor 5-HT4 (5-HT4R, encoded by HTR4). Using Förster resonance energy trans...

The role of serotonin in major depressive disorder (MDD) is the focus of accumulating clinical and preclinical research. The results of these studies reflect the complexity of serotonin signaling through many receptors, in a large number of brain regions, and throughout the lifespan. The role of the serotonin transporter in MDD has been highlighted in gene by environment association studies as ...

L‐DOPA‐induced dyskinesia is a major problem in the treatment of Parkinson’s disease. Today there are few anti‐dyskinetic treatments available for the patients, and all of them have major limitations. Recent findings have revealed an important role of the serotonin system in L‐ DOPA‐induced dyskinesia. In the parkinsonian brain, serotonin axon terminals can compensate for the dopamine loss by c...