this paper presents the effects of different amounts of reclaimed asphalt on fatigue life of asphalt mixtures. central composite method was used to design of experiments based on response surface method (rsm). binder type (pen 60/70 and pen 85/100), reclaimed asphalt pavement (rap) content (25, 50 and 75%) and loading strain (150, 250 and 350 micro strain) were selected as independent variables...

Cell migration underlies tissue formation, maintenance, and regeneration as well as pathological conditions such as cancer invasion. Structural and molecular determinants of both tissue environment and cell behavior define whether cells migrate individually (through amoeboid or mesenchymal modes) or collectively. Using a multiparameter tuning model, we describe how dimension, density, stiffness...

The present paper is devoted to the determination of displacement, stresses and temperature from three dimensional anisotropic half spaces due to presence of heat source. The normal mode analysis technique has been used to the basic equations of motion and generalized heat conduction equation proposed by Green-Naghdi model-II [1]. The resulting equation are written in the form of a vector –matr...

Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in regulating cell fate. To better understand the interplay of biophysical and biochemical effectors in controlling three-dimensional cell migration, a po...

In this article the general non-symmetric parametric form of the incremental secant stiffness matrix for nonlinear analysis of solids have been investigated to present a semi analytical sensitivity analysis approach for geometric nonlinear shape optimization. To approach this aim the analytical formulas of secant stiffness matrix are presented. The models were validated and used to perform inve...

Leaky guided modes propagating along embedded fibers in a composite material can be used for characterizing the fiber-matrix interface. This principle can be applied to real composites containing small-diameter fibers by using laser interferometric detection of very fine lateral resolution on the order of a few microns. The main purpose of this paper is to develop the analytical tools needed to...

Nonenzymatic glycation of connective tissue matrix proteins is a major contributor to the pathology of diabetes and aging. Previously the author and colleagues have shown that nonenzymatic glycation significantly enhances the matrix stability in the Achilles tendon (Reddy et al., 2002, Arch. Biochem. Biophys., 399, 174-180). The present study was designed to gain further insight into glycation-...

Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness. To better understand the effects of stiffness gradients on cell migration, we developed a 2.5D cell culture platform where cells are sandwiched be...