increased levels of proinflammatory cytokines have been recorded after the onset  of transient  or  permanent  brain  ischemia and  are  usually associated with  exacerbation  of ischemic injury. embolic stroke model is more relevant to the pathophysiological situation in such  patients, because the  majority of  ischemic injuries in humans  are induced  by old thrombi that originate from the h...

In order to evaluate the effects of atrial contraction on left ventricular function, the pressure gradient technique was used to measure instantaneous aortic blood flow and pressure in nine patients, six having complete heart block and three having normal sinus rhythm. From these data both left ventricular stroke volume and stroke work were calculated. Ventricular rate was controlled by transve...

A new scintigraphic count-based method for measuring absolute left ventricular volumes is presented. It is a fast and simple technique that allows geometrical assumptions to be avoided and is free of radiation attenuation corrections. This method requires the acquisition of an image of the left ventricle in the right anterior oblique projection and the collection of gated blood pool images in t...

objective(s):every year, a large number of people lose their lives due to stroke. stroke is the second leading cause of death worldwide. surprisingly, recent studies have shown that preconditioning with hyperoxia (ho) increases tissue tolerance to ischemia, ultimately reducing damages caused by stroke. addressed in this study are beneficial contributions from ho preconditioning into reduced har...

background: magnetic resonance imaging (mri) has improved the diagnosis and management of patients with multiple sclerosis (ms). montreal cognitive assessment (moca) is a brief, sensitive test that has been recommended by national institute of neurological diseases and stroke and canadian stroke network (ninds-csn) as a reliable tool to detect mild cognitive impairments. this study aimed to eva...

Objective(s): Stroke is known as a main cause of mortality and prolonged disability in adults. Both transient receptor potential V1 (TRPV1) channels and toll-like receptors (TLRs) are involved in mediating the inflammatory responses. In the present study, the effects of TRPV1 receptor activation and blockade on stroke outcome and gene expression of TLR2 and TLR4 were assessed following permanen...

Background: The aim of the present study was for comparison stroke volume versus variations as guidance fluid management under guide directions electrical cardiometry, during major abdominal surgeries. primary outcome to compare between two infusion protocols, regarding haemodynamic changes, whereas secondary outcomes were evaluate impact each protocol on extravascular lung water and oxygenatio...

In a previous issue of Clinical Science, Remmen et al. [1] addressed the question whether the Modelflow2 method can reliably assess cardiac output (CO) from an arterial pressure waveform without calibration. This question is not new, neither is the answer: it does not, as we have shown in a series of earlier studies [2–5]. If accurate absolute values are required, the methodology needs calibrat...

Left atrial function in patients with hypertensive heart disease was compared with that in control subjects. In patients with hypertensive heart disease, the time constant of left ventricular relaxation was significantly greater than that in controls (54 +/- 18 vs 31 +/- 16 msec; p less than 0.01). The ratio of left ventricular filling volume before atrial contraction (left atrial reservoir vol...