Large genetic association studies based on hundreds of thousands of single-nucleotide polymorphisms (SNPs) are a popular option for the study of complex diseases. The evaluation of gene x gene interactions in such studies is a sensible method of capturing important genetic effects. The number of tests required to consider all pairs of SNPs, however, can lead to a computational burden, and effic...

Multi-level research that attempts to describe ecological effects in themselves (for example, the effect on individual health from living in deprived communities), while also including individual level effects (for example, the effect of personal socioeconomic disadvantage), is now prominent in research on the socioeconomic determinants of health and disease. Such research often involves the ap...

This paper describes a range of theoretical studies into the likely properties of poly-nitrogen molecules (Nn, n>3). In particular, we describe the approach we have used to assess the potential detonation performance of this class of material, and illustrate this with a number of example calculations. We also discuss the implications and limitations of these predictions. In addition, we describ...