PURPOSE The authors identify the signaling pathways for the regulatory volume decrease (RVD) of nonpigmented ciliary epithelial (NPE) cells. The RVD is a regulatory response triggered by swelling and reflecting KCl release by NPE cells. METHODS The cell volumes of human nonpigmented ciliary epithelial cells were measured in suspension by electronic cell sorting. Measurements were conducted in...

background & objectives: odontogenic cysts are among the most frequent destructive lesions of jaws which their pathogenesis and growth mechanism are not cleared. with respect to different roles of mast cells, they may play a role in the pathogenesis and growth of odontogenic cysts. the aim of present study was to evaluate mast cells in the most common odontogenic cyst. methods: thirty  para...

background: endometriosis is a complex estrogen-dependent disease that is defined as the presence of endometrial gland and stroma outside the uterine cavity. although the exact mechanism for the development of endometriosis remains unclear, there is a large body of research data and circumstantial evidence that suggests a crucial role of estrogen in the establishment and maintenance of this dis...

the morphology of retinal photoreceptor layer was studied in continuous light-exposed and dark-adapteddomestic male cats (felis catus). the eyes of 12 healthy adult cats (4 in continuous light-exposed group, 4 in continuous dark-adapted group, and 4 in control group) were routinely fixed and studied by electron microscope. results showed that the general structure of photoreceptor layer in this...

Despite recent improvements in treatment, ovarian cancer is still the leading cause of death from gynaecological malignancies. Today, marine mollusks are considered as natural source of new biologically and pharmacologically active compounds by scientists and the pharmaceutical industries. The aim of this study is to investigate the selective apoptotic effects of Turbo coronatus crude extract f...

Background: Formaldehyde is a chemical that used in fixed tissues and bodies. Formaldehyde during dissection of cadaver, evaporate and be released. Studies have shown that the gas increase endogenous opioids, nitric oxide and cytokines in plasma. These impacts can affect on gonadotropin hormones. The aim of this study was to investigate possible changes in gonadotropin and epithelial cells of t...

the importance of extra cellular matrix (ecm) in development and function of different cells has been reported but little is known about its role in human endometrial epithelial cells. the aim of the present study was to examine effects of artificial ecm (matrigel) and progesterone on the function and morphology of human endometrial epithelial cells in vitro. methods: endometrial samples were r...

Background: This study was undertaken to establish the characterization of cultured oral mucosal epithelium and introducing them as an alternative source for reconstruction of ocular surface disease. Methods: Human oral epithelial cells were cultured on simple media (DMEM/HF12) as control and co-cultured on mitomycin C-treated 3T3 feeder layer, on the amniotic membrane (AM) without nitrocellulo...

Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated into intestinal lumen, however, the mechanism and e...