Paracoccidioidomycosis and histoplasmosis are systemic fungal infections endemic in Brazil. Disseminated clinical forms are uncommon in immunocompetent individuals. We describe two HIV-negative patients with disseminated fungal infections, paracoccidioidomycosis and histoplasmosis, who were diagnosed by biopsies of suprarenal lesions. Both were treated for a prolonged period with oral antifunga...

Due to advancements in transplantation, the concomitant use of immunosuppressive therapies, and the pandemic spread of HIV, the incidence of systemic fungal infections, especially lifethreatening central nervous system (CNS) infections, has increased [1]. CNS fungal infections are associated with high mortality and morbidity. Even in immunocompetent hosts, the cure rate for patients receiving a...

despite the introduction of new antifungal agents, resistances to antifungal therapy continue to increase and outcome of invasive fungal infections treatment is frequently suboptimal. a large amount of the recent effort in antifungal drug discovery has focused on a limited set of targets with functions known or expected to be important for fungal viability and virulence. a variety of techniques...

Prevalence of superficial and systemic mycoses has increased in recent years. The most common etiological factors responsible for those infections are fungi of the genus Candida, mainly Candida albicans; however approximately 35–65% of candidemia cases are caused by other species of this particular genus, described in literature as Candida non-albicans pathogens. Fungal infections have deleteri...

Developing treatment options have resulted in prolonged admission and increased bacterial and fungal nosocomial infections as well as improved survival in neonatal intensive care unit. Invasive fungal infections in newborns are associated with significant morbidity and mortality and can cause endorgan dissemination such as endocarditis, endophthalmitis, septic arthritis, obstructive nephropathy...

BACKGROUND AND OBJECTIVES Infections represent the major complications following allogeneic stem cell transplantation (SCT). A promising marker for a more specific and early detection of bacterial or fungal infections is procalcitonin (PCT). DESIGN AND METHODS Maximum values (m) and increase (Delta) of PCT and C-reactive protein (CRP) were prospectively analyzed during 214 clinical events in ...