نتایج جستجو برای: t cell inhibitor
تعداد نتایج: 2296471 فیلتر نتایج به سال:
Abstract The inside of a cell is highly crowded with proteins and other biomolecules. How express their specific functions together many off-target in cellular environments largely unknown. Here, we investigate an inhibitor binding c-Src kinase using atomistic molecular dynamics (MD) simulations dilute as well protein solution. populations the inhibitor, 4-amino-5-(4-methylphenyl)?7-( t -butyl)...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant hematological disorder arising in the thymus from T-cell progenitors. T-ALL mainly affects children and young adults, and remains fatal in 20% of adolescents and 50% of adults, despite progress in polychemotherapy protocols. Therefore, innovative targeted therapies are desperately needed for patients with a dismal prognosis....
بررسی بیان ژنهای دخیل در سیستم دفاعی گندم نسبت به mycosphaerella graminicola با استفاده از cdna-aflp
aflp یک ابزار قدرتمند برای تشخیص رونوشت هایی با فراوانی کم است و می تواند بعنوان یک روش کارآمد برای جداسازی ژنهایی که بطور متمایز بیان می شوند، بکار رود. بنابراین القا متمایز ژنها در گندم ( رقم چمران و مرودشت) در پاسخ به قارچ m.graminicola بوسیله آنالیز cdna-aflp مورد مطالعه قرار گرفت . در ابتدا گیاهان بوسیله بیمارگر مایه زنی شدند. نمونه برداری در 6 نقطه زمانی(0، 12، 24، 48، 72 و 96 ساعت) بعد ا...
background: primary cutaneous lymphomas (pcls) represent a heterogeneous group of t- and b-cell lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. the aim of this study was to assess and report the epidemiological characteristics of pcls in isfahan, isfahan province, iran — as a main province of iran. materials and methods: a total of 99 pati...
PURPOSE To evaluate the effects of BRAF inhibition on the tumor microenvironment in patients with metastatic melanoma. EXPERIMENTAL DESIGN Thirty-five biopsies were collected from 16 patients with metastatic melanoma pretreatment (day 0) and at 10 to 14 days after initiation of treatment with either BRAF inhibitor alone (vemurafenib) or BRAF + MEK inhibition (dabrafenib + trametinib) and were...
1589 Single-cell RNA sequencing analysis of human psoriatic skin with SLE treated with IL23 blockade
Systemic lupus erythematosus (SLE) and psoriasis are both chronic immune-mediated diseases. SLE is caused by T-helper 1 (Th1), Th2, Th17, B cell axis activation, while primarily driven Th17 activation. Coexistent has been reported. A phase II trial of patients with active demonstrated that ustekinumab (interleukin (IL)12 23 blockade) resulted in significant Responder Index improvement when adde...
Abstract Background: Presence of the beta-lactamase enzyme results in microbial resistance to beta-lactam and cell wall synthesis inhibitor antibiotics. This study was conducted to compare effects of Calendula officinalis extract and cephalosporines, as a cell wall synthesis inhibitor antibiotic, on bacteria isolated from patients with cellulitis. Methods: This experimental study was done o...
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