tau protein isolated from porcine brain microtubules was further purified by electrophoretic elution from polyacrylamide gels and used to prepare antisera in rabbits. The antiserum to tau specifically stains mitotic spindles and a filamentous network within mouse fibroblasts when the indirect immunofluorescence technique is used. The staining of the filamentous network and mitotic spindles is i...

Tau is hyperphosphorylated in the brains of patients with tauopathies, such as Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). However, neither the mechanism of hyperphosphorylation nor its contribution to pathogenesis is known. We applied Phos-tag SDS-PAGE, a phosphoaffinity electrophoresis, to the analysis of tau phosphorylation in vitro by ...

In this paper the periodic solutions of fourth order delay differential equation of the form $ddddot{x}(t)+adddot{x}(t)+f(ddot{x}(t-tau(t)))+g(dot{x}(t-tau(t)))+h({x}(t-tau(t)))=p(t)$  is investigated. Some new positive periodic criteria are given.  

Tau is a microtubule-associated protein which regulates the assembly and stability of microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (NFTs), a pathological hallmark in Alzheimer's disease (AD). A characteristic of AD tau is hyperphosphorylation with more than 40 phosphorylation sites. Aggregates of hyperphosphorylated tau are also found in other n...

With the emerging proteomics era the scientific community is beginning the daunting task of understanding the structures and functions of a large number of selfassembling proteins. Here, our study was concerned with the effect of the microtubuleassociated-protein (MAP) tau on the assembled structure of taxol-stabilized microtubules. Significantly, the synchrotron small angle x-ray scattering (S...

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain nucleus accumbens were studied by the microdialysis technique coupled to HPLC-EC detection. Levels of GLU and GABA were not affected by ethanol, whereas those of TAU were increased by doses of the ...

Interactive Evolutionary Algorithms (IEAs) are a powerful explorative search technique that utilizes human input to make subjective decisions on potential problem solutions. But humans are slow and get bored and tired easily, limiting the usefulness of IEAs. Here we describe our system which works toward overcoming these problems, The Approximate User (TAU), and also a simulated user as a means...

We present a new technique, which is the distal perfusion first technique, for chronic dissection with dilatation of the aorta. Using a "side-ways-tau shaped" incision, this technique allows single-staged repair, full-time antegrade perfusion, less possibility of mesenteric malperfusion and cerebral embolism.