The potential action of cytotoxic agents such as alkylating drugs and antimetabolites on the immune response and inflammatory process has suggested their trial in the treatment of rheumatic diseases. Nitrogen mustard was tried initially both by intravenous and intra-articular injection in the therapy of rheumatoid arthritis and gave variable responses (Jimenez Diaz, 1951; Jimenez Diaz, Lopez Ga...

Chronic diseases are often accompanied by inflammatory and degenerative processes. Estrogens have repeatedly been found to be involved in these processes. Testosterone (T) is the main precursor of estrogen in the brain and T replacement in chronic diseases has become important in recent years, prompting research on new T-conjugated molecules. We recently synthesized three new molecules includin...

In this article, a layered shell element-based, elastic finite element method for predicting welding distortion in multi-pass is developed. The generated each pass can be predicted by employing layer-by-layer equivalent plastic strains as thermal expansion coefficients and using the heat-affected zone (HAZ) width mesh size. final expressed sum of distortions pass. This study focuses on extracti...

Many cancer therapeutic agents have been used for experimental and clinical purposes. It has been established that generally such agents are toxic to embryos with highly mitotic activities as well as other rapidly growing or proliferating tissues. The teratogenicity of these agents has been shown in rodents (Reviewed by Nishimura, '64; Karnof sky, '65; Dagg, '66). Murphy et at. ('58) found that...

BACKGROUND High-dose chemotherapy in combination with peripheral blood progenitor cell transplantation is widely used in the treatment of several malignancies. The use of high-dose chemotherapy can be complicated by the occurrence of severe and sometimes life threatening toxicity. A wide interpatient variability in toxicity is encountered, which may be caused by variability in the pharmacokinet...

A bioassay of thio-TEPA for possible carcinogenicity was conducted by administering the test chemical by intraperitoneal injection to Sprague-Dawley rats and B6C3F1 mice. Groups of 31-39 rats of each sex were administered thio-TEPA in phosphate-buffered saline at one of three doses, either 0.7, 1.4, or 2.8 mg/kg body weight, three times per week for a maximum of 52 weeks, then observed for addi...

The harmful effects of 14 chemotherapeutic drugs on spermatogenesis in the mouse have been evaluated by studies of testicular cell killing and morphological and genetic damage produced. Male mice were given drugs as single injections at various doses up to the toxic levels. Prednisone and 6-mercaptopurine produced little or no cytotoxicity. All other drugs tested killed differentiated spermatog...

Genetic therapy using microRNA-499 (miR-499) was combined with chemotherapy for the advanced treatment of cancer. Our previous study showed that miR-499 suppressed tumor growth through the inhibition of vascular endothelial growth factor (VEGF) production and subsequent angiogenesis. In the present study, we focused on blood flow in tumors treated with miR499, since some angiogenic vessels are ...

We read with interest the report by Holmsen and Leasure (1) in which they reported the growth-inhibiting property of tris(1-aziridinyl)phosphine oxide (APO) on grasses. We feel that one of the most important biological properties of the chemical was not mentioned in the report, namely, the ability to induce mutations. Indeed APO is a powerful mutagen; APO (or triethylenephosphoramide, TEPA) pro...