INTRODUCTION Renal involvement is a rare complication of β-thalassemia. Both tubular and glomerular dysfunction might occur in these patients. The aim of this study was to evaluate and compare kidney function in the major, intermedia, and minor variants of β-thalassemia. MATERIALS AND METHODS Renal tubular and glomerular function of 72 patients with β-thalassemia (25 major, 23 intermedia, and...

The red cell distribution width (RDW) is an index of the variation in red cells size (anisocytosis). A study was conducted to examine the validity of using RDW in improving classification of microcytic anaemias. A total of 300 blood samples collected from a patient population aged 3 months to 55 years who were referred for haemoglobin electrophoresis were examined at the Aga Khan University Hos...

BACKGROUND Thalassemia is the most common monogenic disease in South-East of Iran. Despite the 70% reduction in Iranian thalassemia cases after thalassemia control comprehensive program, 601 affected babies were born in Sistan and Balouchistan Province, Iran from 2002 to 2010, so this study aims at investigating the causes of new thalassemia cases. METHODS Data from this retrospective cross-s...

background and aims: iron deficiency anemia (ida) and beta thalassemia minor (btm) are the most common hypochromic microcytic anemias, and it is regarded important to differentiate between them. several formulae can be taken into consideration based on red blood cell (rbc) parameters in order to distinguish between these two disorders. hence, the present study intended to evaluate the sensitivi...

Introduction and Objective: Zinc as the second trace element of the human body plays an important role in numerous functions. A large number of research studies have showed serum zinc deficiency and excess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary zinc excretion in minor b...

Hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly Mediterranean and Middle Eastern countries. Hemoglobinopathies include structural variants of hemoglobin (Hb S, Hb C, HbE,…) and thalassaemias which are inherited defects in the globin chains synthesis. The present study was conducted to determine the prevalence of h...

Objectives:to evaluate Pentraxin-3 Levels (PTX-3) in pediatric patients with β-thalassemia major, intermedia and minor its relationship antioxidant capacity total oxidant stress.