background continuous epidural analgesia with catheterization is a useful technique, because it has a wide adaptation range and provides prolonged analgesia. problems that may arise from long-term epidural analgesia are changes in the analgesic area, duration of analgesia and catheter-related problems. few articles have evaluated gradual changes of long-term epidural analgesia. in the animal mo...

To examine the ethical issues involved in governmental decisions with potential health risks, we review the history of the decision to raise the interurban speed limit in Israel in light of its impact on road death and injury. In 1993, the Israeli Ministry of Transportation initiated an "experiment" to raise the interurban speed limit from 90 to 100 kph. The "experiment" did not include a proto...

Passive immunotherapy has mainly been used as a therapy against cancer and inflammatory conditions. Recent studies have shown that monoclonal antibody-(mAb-) based passive immunotherapy is a promising approach to combat virus infection. Specific mouse mAbs can be routinely generated in large amounts with the use of hybridoma technology but these cannot be used for therapy in human beings due to...

'What is it that appears to make the mentally ill so vulnerable to therapeutic experimentation?'(1) One commentator wrote in the 1990s, regarding mental hospitals as repressive, coercive and custodial institutions where medical staff subjected patients to orgies of experimentation. A careful study of surviving documents of the Devon County Lunatic Asylum (DCLA), however, paints a different pict...

Throughout this text we will analyze some human concerns that are the subject of analysis in different fields knowledge such as philosophy, art, science and technology. These revolve around what is reality? fiction? effects hallucination? virtuality? through cultural products literature, cinema, psychoactive or entheogenic experiences, up to most recent proposals Virtual Reality their forms int...