Migraine is a widespread disorder that affects about 18% of the people, in 2/3 of cases women (1). The concept that migraine could be related to some vascular diseases, such as myocardial infarction or a stroke, have grown over the years, mainly in migraine with aura (2–6). In the last decades, several studies have been carried out to understand if and what the linkage could be. Among these stu...

Thrombophilia is defined as a condition predisposing to the development of venous thromboembolism (VTE) on the basis of a hypercoagulable state. Over the past decades, great advances in the pathogenesis of VTE have been made and nowadays it is well established that a thrombophilic state may be associated with acquired and/or inherited factors. The rare loss-of-function mutations of the genes en...

Acquired and inherited thrombophilic factors increase the risk for (recurrent) venous thrombotic disease. However, little is known about the pathophysiological mechanisms causing these recurrences, or the persistence of thrombosis despite adequate treatment. Because residual thrombosis has been associated with a worse prognostic outcome, we performed an explorative study in order to investigate...

OBJECTIVE The increased risk for thrombosis is known as hypercoagulability or thrombophilia. In our study, we aimed to compare the frequency of the identified defects for thrombophilia in patients with central venous thrombosis and under the age of 50 years, with the findings in the current literature. METHODS Forty-three patients (16-50 years old) were retrospectively evaluated. Thrombophili...

Cancer and its related therapies are acquired thrombophilic risk factors. Patients with a malignancy can suffer a thrombotic complication such as deep venous thrombosis (DVT) in the lower extremities with a possible following pulmonary embolism. Recently, an increased association between upper extremity DVT and malignancy has been observed and several risk factors were identified. However, few ...

AIM One of the main problems concerning repeated spontaneous miscarriage (RSM) is the etiological diagnosis. The relation of thrombophilia to RSM is a matter of debate. In this case-control study, we determined the percentages of three thrombophilic mutations (factor V leiden, prothrombin, and methylenetetrahydrofolate reductase) amongst 20 cases with RSM and 20 control normal parous women. R...

Although hypercoagulable states are most often associated with venous thromboses, arterial thromboses are reported in protein C, protein S, antithrombin deficient patients and in those with factor V Leiden, components of hereditary thrombophilia. Because these arterial thromboses (peripheral artery disease, myocardial infarction, and cerebral infarction) mostly affect young persons, aged below ...

Splanchnic vein thrombosis (SVT) – including mesenteric, portal, splenic and supra-hepatic veins thrombosis – is an underdiagnosed disease, with heterogeneous clinical presentations and a non-negligible rate of incidental findings. The main risk factors include abdominal diseases or interventions (e.g. infections, cirrhosis, abdominal cancer or surgical procedures), haematological disorders (ma...