The objective of this analysis was to explore exposure-response modeling of data from a thorough QT (TQT) study of tolterodine in CYP2D6 extensive (EMs) and poor metabolizers (PMs). Crossover treatments of the TQT study included the recommended (2 mg twice daily) and supratherapeutic (4 mg twice daily) doses of tolterodine, moxifloxacin (400 mg once daily), and placebo. The concentration-respon...

OBJECTIVE To compare tolterodine with oxybutynin in treatment of urge incontinence. STUDY DESIGN A systematic review, following Cochrane methods, was performed to retrieve results of randomized trials that compared tolterodine with oxybutynin in adults with urge incontinence. Composite point estimates of efficacy (episodes of incontinence per 24-hour period, frequency, and voided volume) and ...

CONTEXT Men with overactive bladder and other lower urinary tract symptoms may not respond to monotherapy with antimuscarinic agents or alpha-receptor antagonists. OBJECTIVE To evaluate the efficacy and safety of tolterodine extended release (ER), tamsulosin, or both in men who met research criteria for both overactive bladder and benign prostatic hyperplasia. DESIGN, SETTING, AND PARTICIPA...

Objective: Urinary incontinence is defined as urinary that a social or hygienic problem and can be objectively demonstrated. It aimed to compare tolterodine, trospium chloride solifenacin treatments, its side effects on patients who have complaints of pure mixed incontinence.
 Material Method: Totally 98 patients, applied Ankara Etlik Zubeyde Hanım Gynecology Training Research Hospital, Ur...

BACKGROUND Bladder discomfort related to intraoperative catheterization of urinary bladder is a distressing symptom and more so in patients awakening from anaesthesia. These symptoms are similar to symptoms of overactive bladder. Muscarinic receptor antagonists have been reported to be effective in the treatment of overactive bladder. This study was therefore undertaken to evaluate the efficacy...

A new sensitive, simple, rapid and precise reversed phase high performance liquid chromatographic (HPLC) and a spectrophotometric method has been developed for estimation of tolterodine in tablet dosage form. Chromatography was performed by using the mobile phase, Potassium Phosphate pH 4.5 and acetonitrile mixed by a low pressure gradient program. Hypersil BDS C18 column was used. The waveleng...

PURPOSE To evaluate the efficacy of intermittent percutaneous needle sacral nerve stimulation (IPN-SNS) in women with idiopathic overactive bladder (IOAB) treated with tolterodine. MATERIALS AND METHODS A total of 240 female patients diagnosed with IOAB were randomized to receive tolterodine only treatment (group 1, n = 120) or tolterodine combined with IPN-SNS (group 2, n = 120). Each group ...