The comparative in vitro skin permeability of diclofenac sodium through excised mouse skin from different common pharmaceutical vehicles like castor oil, olive oil, arachis oil, liquid paraffin, white soft paraffin melt, 3% sodium carboxymethyl cellulose (CMC) aqueous gel and isopropyl myristate (IPM), excluding other excipients was evaluated. Significantly (p < 0.05) higher flux of diclofenac ...

The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin through the excised rat epidermis from 2% w/w CRB and HPC gel system was investi...

Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is present in the intercellular matrix of most vertebrate connective tissues especially skin where it has a protective, structure stabilizing and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and non-immunogen...

background and aims: osteoarthritis is one of the most common arthritis in elderly. we evaluated to compare the effect of topical application of eugenia caryophylata extract and topical diclofenac in primary knee osteoarthritis.methods: this randomized double-blind clinical trial study was carried out upon 105 patients with primary knee osteoarthritis. patients were selected randomly and divide...

Prevention of nonmelanoma skin cancers remains a health priority due to high costs associated with this disease. Diclofenac and difluoromethylornithine (DFMO) have demonstrated chemopreventive efficacy for cutaneous squamous cell carcinomas. We designed a randomized study of the combination of DFMO and diclofenac in the treatment of sun-damaged skin. Individuals with visible cutaneous sun damag...

BACKGROUND Topical NSAIDs have been proven to relieve the symptoms of osteoarthritis (OA) in short-term studies (2 weeks). To justify its chronic use, efficacy of a topical NSAID over a longer term of study should be demonstrated. The efficacy and safety of a topical diclofenac solution over a 6-week treatment course in symptomatic primary OA of the knee was investigated. METHODS 216 men and ...

BACKGROUND Topical formulations of non-steroidal anti-inflammatory drugs (NSAIDs), in particular diclofenac (DI), have become popular for treating various acute and chronic painful inflammatory conditions. OBJECTIVE To perform a literature review of (1) the use of topical NSAIDs; (2) the pharmaceutical, pharmacokinetic and pharmacodynamic properties of a medicated plaster (patch) containing d...