Abstract Background: Soil dust has been debated about its effects on public health and the challenge is brought about tuberculosis (TB). The purpose of this study was to investigate the influence of soil dust on pulmonary tuberculosis (PTB) prevalence and its control indices. Methods: The medical files of patients in Khuzestan Health Center were reviewed. The control group included the PTB...

analysis of  receptor–ligand  interactions  in  the  context  of  diseases  necessitates  to understand how hla–kir genotypes function in diseases. although cd56+  lymphocytes are derived from multiple lineages, they share a functional association with immunosurviellance and antimicrobial responses. the present study aimed to determine whether kir phenotype in cd56 lymphocytes and corresponding...

tuberculosis (tb) and tobacco use are two major alarming global health issues posing immense threats to human populations. mycobacterium tuberculosis (mtb) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as cxcl-8, il-12 and tnf-α which in turn induces the immune system network. however no information is available on other ...

background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

tuberculosis is one of the most common infectious diseases in the world. in recent years, genetically approach has been developed. one of the interesting gene for investigator is ifn-γr1. in this study we determind susceptibility to tuberculosis with polymorphism of ifn-γr1 gene. fifthly patients with smear positive tuberculosis have been chosen randomly. they were matched with 54 healthy contr...

background: pulmonary tuberculosis is still the most common form of tuberculosis in hiv infected patients having differ­ent presentations according to the degree of immunosuppression. this study appraised the impact of hiv infection on clini­cal, laboratory and radiological presentations of tuberculosis. methods: the clinical, laboratory and radiological presentations of pulmonary tb in 56 hiv-...

Objective(s): Detection of circulating Mycobacterium tuberculosis (M. tuberculosis) antigens is promising in Tuberculosis (TB) diagnosis. However, not a single antigen marker has been found to be widely expressed in all TB patients. This study is aimed to prepare broadly reactive polyclonal antibodies targeting multiple antigen markers (multi-target antibodies) and evaluate their efficacies in ...

multidrug-resistant (mdr) and extensively drug-resistant (xdr) tuberculosis (tb) are increasing globally. treatment options for these patients are very limited. although treatment of these patients with standardized regimen is associated with high mortality and morbidity, rational usage of new drugs might be promising. in this study we will review epidemiology of xdr-tb and tdr-tb in iran and t...